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A detrimental role for invariant natural ...
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Document type :
Article dans une revue scientifique
DOI :
10.1016/j.ajpath.2011.06.023
PMID :
21843496
Title :
A detrimental role for invariant natural killer T cells in the pathogenesis of experimental dengue virus infection
Author(s) :
Renneson, Joelle [Auteur]
Institut Pasteur de Lille
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Guabiraba, Rodrigo [Auteur]
Infectiologie Animale et Santé Publique [UR IASP]
Maillet, Isabelle [Auteur]
Immunologie et Embryologie Moléculaires [IEM]
Marques, Rafael E. [Auteur]
Ivanov, Stoyan [Auteur]
Institut Pasteur de Lille
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Fontaine, Josette [Auteur]
Institut Pasteur de Lille
Paget, Christophe [Auteur]
Institut Pasteur de Lille
Quesniaux, Valérie [Auteur]
Immunologie et Embryologie Moléculaires [IEM]
Faveeuw, Christelle [Auteur]
Institut Pasteur de Lille
Ryffel, Bernhard [Auteur]
Immunologie et Embryologie Moléculaires [IEM]
Teixeira, Mauro M. [Auteur]
Trottein, Francois [Auteur correspondant]
Institut Pasteur de Lille
Journal title :
American Journal of Pathology
Pages :
1872-1883
Publisher :
American Society for Investigative Pathology
Publication date :
2011
ISSN :
0002-9440
HAL domain(s) :
Sciences du Vivant [q-bio]/Immunologie
English abstract : [en]
Dengue virus (DENV), a member of the mosquito-borne flaviviruses, is a serious public health problem in many tropical countries. We assessed the in vivo physiologic contribution of invariant natural killer T (iNKT) cells, ...
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Dengue virus (DENV), a member of the mosquito-borne flaviviruses, is a serious public health problem in many tropical countries. We assessed the in vivo physiologic contribution of invariant natural killer T (iNKT) cells, a population of nonconventional lipid-reactive alphabeta T lymphocytes, to the host response during experimental DENV infection. We used a mouse-adapted DENV serotype 2 strain that causes a disease that resembles severe dengue in humans. On DENV challenge, splenic and hepatic iNKT cells became activated insofar as CD69 and Fas ligand up-regulation and interferon-gamma production. C57BL/6 mice deficient in iNKT cells (Jalpha18(-/-)) were more resistant to lethal infection than were wild-type animals, and the phenotype was reversed by adoptive transfer of iNKT cells to Jalpha18(-/-) animals. The absence of iNKT cells in Jalpha18(-/-) mice was associated with decreased systemic and local inflammatory responses, less liver injury, diminished vascular leak syndrome, and reduced activation of natural killer cells and neutrophils. iNKT cell functions were not necessary for control of primary DENV infection, after either natural endogenous activation or exogenous activation with the canonical iNKT cell agonist alpha-galactosylceramide. Together, these data reveal a novel and critical role for iNKT cells in the pathogenesis of severe experimental dengue disease.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Comment :
Renneson, Joelle Guabiraba, Rodrigo Maillet, Isabelle Marques, Rafael E Ivanov, Stoyan Fontaine, Josette Paget, Christophe Quesniaux, Valerie Faveeuw, Christelle Ryffel, Bernhard Teixeira, Mauro M Trottein, Francois Am J Pathol. 2011 Oct;179(4):1872-83. doi: 10.1016/j.ajpath.2011.06.023. Epub 2011 Aug 16.
Collections :
  • Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Source :
Harvested from HAL
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  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181339/pdf
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