Regulation of the immune response to α-Gal ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
PMID :
Titre :
Regulation of the immune response to α-Gal and vector-borne diseases
Auteur(s) :
Cabezas-Cruz, Alejandro [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Mateos-Hernandez, Lourdes [Auteur]
Pérez-Cruz, Magdiel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Valdes, James J. [Auteur]
Mera, Isabel G. Fernández De [Auteur]
Villar, Margarita [Auteur]
de La Fuente, Jose [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Mateos-Hernandez, Lourdes [Auteur]
Pérez-Cruz, Magdiel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Valdes, James J. [Auteur]
Mera, Isabel G. Fernández De [Auteur]
Villar, Margarita [Auteur]
de La Fuente, Jose [Auteur correspondant]
Titre de la revue :
Trends in parasitology
Pagination :
470-476
Éditeur :
Elsevier
Date de publication :
2015
ISSN :
1471-4922
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response ...
Lire la suite >Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Gala1-3Galb1-(3)4GlcNAc-R (a-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-a-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of a-gal. Establishing the source of a-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.Lire moins >
Lire la suite >Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Gala1-3Galb1-(3)4GlcNAc-R (a-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-a-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of a-gal. Establishing the source of a-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Commentaire :
Contribution: Conceived the idea and drafted the manuscript
Source :