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NOD2 prevents emergence of disease-predisposing ...
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Document type :
Article dans une revue scientifique
DOI :
10.4161/gmic.25275
PMID :
23778641
Title :
NOD2 prevents emergence of disease-predisposing microbiota
Author(s) :
Secher, Thomas [Auteur]
Centre de Physiopathologie Toulouse Purpan [CPTP]
Normand, Sylvain [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Chamaillard, Mathias [Auteur] refId
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Journal title :
Gut Microbes
Pages :
353-356
Publisher :
Taylor & Francis
Publication date :
2013-07
ISSN :
1949-0976
English keyword(s) :
Crohn disease
colorectal cancer
dysbiosis
fecal transplantation
nucleotide-binding oligomerization domain protein 2
HAL domain(s) :
Sciences du Vivant [q-bio]/Cancer
English abstract : [en]
The gut flora is composed of a huge number of diverse, well-adapted symbionts that interact with epithelial lining throughout the host's entire life. Not all commensals have the same ability to maintain quiescent, protective ...
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The gut flora is composed of a huge number of diverse, well-adapted symbionts that interact with epithelial lining throughout the host's entire life. Not all commensals have the same ability to maintain quiescent, protective inflammation. Importantly, instability in the composition of gut microbial communities (referred to as dysbiosis) has been linked to loss of gut barrier in the context of common human illnesses with increasing socio-economic impacts, such as Crohn disease and colorectal cancer. Our recent findings suggest that disease-predisposing dysbiosis can now be intentionally manipulated by targeting the major Crohn disease-predisposing NOD2 gene. That knowledge will not only add a new dimension to the often overlooked microbiology of Crohn disease and colorectal cancer, but will also have a broad impact on biomedical sciences worldwide.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
  • Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Source :
Harvested from HAL
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  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744520/pdf
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