Title :

Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

Author(s) :

Kabbara, Samar [Auteur]
Groupe d'Étude des Interactions Hôte-Pathogène [GEIHP]
Herivaux, Anais [Auteur]
Groupe d'Étude des Interactions Hôte-Pathogène [GEIHP]
Dugé de Bernonville, Thomas [Auteur]
Biomolécules et biotechnologies végétales [BBV EA 2106]
Courdavault, Vincent [Auteur]
Biomolécules et biotechnologies végétales [BBV EA 2106]
Clastre, Marc [Auteur]
Biomolécules et biotechnologies végétales [BBV EA 2106]
Gastebois, Amandine [Auteur]
Groupe d'Étude des Interactions Hôte-Pathogène [GEIHP]
Osman, Marwan [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Hamzé, Monzer [Auteur]
Cock, J Mark [Auteur]
Laboratoire de Biologie Intégrative des Modèles Marins [LBI2M]
Schaap, Pauline [Auteur]
Papon, Nicolas [Auteur]
Groupe d'Étude des Interactions Hôte-Pathogène [GEIHP]

Journal title :

Genome Biology and Evolution

Pages :

86-108

Publisher :

Society for Molecular Biology and Evolution

Publication date :

2019

ISSN :

1759-6653

English keyword(s) :

histidine kinases
cell signaling
two-component systems
eukaryotes
phylogenetic analysis

HAL domain(s) :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]

English abstract : [en]

Histidine kinases (HKs) are primary sensor proteins that act in cell signaling pathways generically referred to as “two-component systems” (TCSs). TCSs are among the most widely distributed transduction systems used by ...
Show more >Histidine kinases (HKs) are primary sensor proteins that act in cell signaling pathways generically referred to as “two-component systems” (TCSs). TCSs are among the most widely distributed transduction systems used by both prokaryotic and eukaryotic organisms to detect and respond to a broad range of environmental cues. The structure and distribution of HK proteins are now well documented in prokaryotes, but information is still fragmentary for eukaryotes. Here, we have taken advantage of recent genomic resources to explore the structural diversity and the phylogenetic distribution of HKs in the prominent eukaryotic supergroups. Searches of the genomes of 67 eukaryotic species spread evenly throughout the phylogenetic tree of life identified 748 predicted HK proteins. Independent phylogenetic analyses of predicted HK proteins were carried out for each of the major eukaryotic supergroups. This allowed most of the compiled sequences to be categorized into previously described HK groups. Beyond the phylogenetic analysis of eukaryotic HKs, this study revealed some interesting findings: 1) characterization of some previously undescribed eukaryotic HK groups with predicted functions putatively related to physiological traits; 2) discovery of HK groups that were previously believed to be restricted to a single kingdom in additional supergroups, and 3) indications that some evolutionary paths have led to the appearance, transfer, duplication, and loss of HK genes in some phylogenetic lineages. This study provides an unprecedented overview of the structure and distribution of HKs in the Eukaryota and represents a first step toward deciphering the evolution of TCS signaling in living organisms.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL