Title :

Dual role of the Anopheles coluzzii Venus Kinase Receptor in both larval growth and immunity

Author(s) :

Gouignard, Nadège [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cherrier, Floriane [Auteur]
Génétique et Génomique des Insectes Vecteurs
Brito-Fravallo, Emma [Auteur]
Génétique et Génomique des Insectes Vecteurs
Pain, Adrien [Auteur]
Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB
Génétique et Génomique des Insectes Vecteurs
Zmarlak, Natalia Marta [Auteur]
Génétique et Génomique des Insectes Vecteurs
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Genève, Corinne [Auteur]
Génétique et Génomique des Insectes Vecteurs
Vernick, Kenneth D [Auteur]
Génétique et Génomique des Insectes Vecteurs
Dissous, Colette [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Mitri, Christian [Auteur correspondant]
Génétique et Génomique des Insectes Vecteurs

Journal title :

SCIENTIFIC REPORTS

Pages :

3615

Publisher :

Nature Publishing Group

Publication date :

2019-03-05

ISSN :

2045-2322

HAL domain(s) :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire
Sciences du Vivant [q-bio]/Biologie de la reproduction/Reproduction sexuée
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie

English abstract : [en]

Vector-borne diseases and especially malaria are responsible for more than half million deaths annually. The increase of insecticide resistance in wild populations of Anopheles malaria vectors emphasises the need for novel ...
Show more >Vector-borne diseases and especially malaria are responsible for more than half million deaths annually. The increase of insecticide resistance in wild populations of Anopheles malaria vectors emphasises the need for novel vector control strategies as well as for identifying novel vector targets. Venus kinase receptors (VKRs) constitute a Receptor Tyrosine Kinase (RTK) family only found in invertebrates. In this study we functionally characterized Anopheles VKR in the Gambiae complex member, Anopheles coluzzii. Results showed that Anopheles VKR can be activated by L-amino acids, with L-arginine as the most potent agonist. VKR was not required for the fecundity of A. coluzzii, in contrast to reports from other insects, but VKR function is required in both Anopheles males and females for development of larval progeny. Anopheles VKR function is also required for protection against infection by Plasmodium parasites, thus identifying a novel linkage between reproduction and immunity in Anopheles. The insect specificity of VKRs as well as the essential function for reproduction and immunity suggest that Anopheles VKR could be a potentially druggable target for novel vector control strategies.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Integrative Biology of Emerging Infectious Diseases

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL