Title :

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.

Author(s) :

Lamas, Bruno [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Richard, Mathias L [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Leducq, Valentin [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Pham, Hang-Phuong [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Michel, Marie-Laure [Auteur]
da Costa, Gregory [Auteur]
Bridonneau, Chantal [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Jegou, Sarah [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Hoffmann, Thomas W [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Natividad, Jane M [Auteur]
Brot, Loic [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Taleb, Soraya [Auteur]
Paris-Centre de Recherche Cardiovasculaire [PARCC - UMR-S U970]
Couturier-Maillard, Aurélie [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Nion-Larmurier, Isabelle [Auteur]
Service de Gastroentérologie et nutrition [CHU Saint-Antoine]
Merabtene, Fatiha [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Seksik, Philippe [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Bourrier, Anne [Auteur]
Service de Gastroentérologie et nutrition [CHU Saint-Antoine]
Cosnes, Jacques [Auteur]
Service de Gastroentérologie et nutrition [CHU Saint-Antoine]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Ryffel, Bernhard [Auteur]
Immunologie et Neurogénétique Expérimentales et Moléculaires [INEM]
Beaugerie, Laurent [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Launay, Jean Marie [Auteur]
Langella, Philippe [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Xavier, Ramnik J [Auteur]
Technicolor [Cesson Sévigné]
Sokol, Harry [Auteur]
Service de Gastroentérologie et nutrition [CHU Saint-Antoine]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Université Pierre et Marie Curie - Paris 6 [UPMC]

Journal title :

Nature Medicine

Pages :

598–605

Publisher :

Nature Publishing Group

Publication date :

2016-05-09

ISSN :

1078-8956

Keyword(s) :

mucosal immunology

English keyword(s) :

inflammatory bowel disease

HAL domain(s) :

Chimie/Chimie organique

English abstract : [en]

Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 ...
Show more >Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 (CARD9), a susceptibility gene for inflammatory bowel disease (IBD) that functions in the immune response against microorganisms. CARD9 promotes recovery from colitis by promoting interleukin (IL)-22 production, and Card9-/- mice are more susceptible to colitis. The microbiota is altered in Card9-/- mice, and transfer of the microbiota from Card9-/- to wild-type, germ-free recipients increases their susceptibility to colitis. The microbiota from Card9-/- mice fails to metabolize tryptophan into metabolites that act as aryl hydrocarbon receptor (AHR) ligands. Intestinal inflammation is attenuated after inoculation of mice with three Lactobacillus strains capable of metabolizing tryptophan or by treatment with an AHR agonist. Reduced production of AHR ligands is also observed in the microbiota from individuals with IBD, particularly in those with CARD9 risk alleles associated with IBD. Our findings reveal that host genes affect the composition and function of the gut microbiota, altering the production of microbial metabolites and intestinal inflammation.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL