Titre :

Gut microbiome and anticancer immune response: really hot Sh(star)t!

Auteur(s) :

Viaud, S. [Auteur]
Immunologie des tumeurs et immunothérapie [UMR 1015]
Daillere, R. [Auteur]
Immunologie des tumeurs et immunothérapie [UMR 1015]
Boneca, I. G. [Auteur]
Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall [BGPB]
Lepage, Patricia [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Langella, Philippe [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Chamaillard, M. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pittet, M. J. [Auteur]
Harvard Medical School [Boston] [HMS]
Massachusetts General Hospital [Boston]
Ghiringhelli, F. [Auteur]
Université de Bourgogne [UB]
Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] [UNICANCER/CRLCC-CGFL]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Trinchieri, G. [Auteur]
National Cancer Institute [Bethesda] [NCI-NIH]
Goldszmid, R. [Auteur]
National Cancer Institute [Bethesda] [NCI-NIH]
Zitvogel, L. [Auteur]
Centre d'Investigation Clinique en Biotherapie des cancers [CIC 1428 , CBT 507 ]
Immunologie des tumeurs et immunothérapie [UMR 1015]

Titre de la revue :

Cell death and differentiation

Pagination :

199 - 214

Éditeur :

Nature Publishing Group

Date de publication :

2014-05-16

ISSN :

1350-9047

Mot(s)-clé(s) en anglais :

GERM-FREE MICE
INDUCED COLITIS
COLON TUMORIGENESIS
LUNG-CANCER
INNATE IMMUNITY
COLORECTAL-CANCER
BETA-GLUCURONIDASE
TOLL-LIKE RECEPTORS
INFLAMMATORY-BOWEL-DISEASE
INTESTINAL EPITHELIAL-CELLS

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The impact of gut microbiota in eliciting innate and adaptive immune responses beneficial for the host in the context of effective therapies against cancer has been highlighted recently. Chemotherapeutic agents, by ...
Lire la suite >The impact of gut microbiota in eliciting innate and adaptive immune responses beneficial for the host in the context of effective therapies against cancer has been highlighted recently. Chemotherapeutic agents, by compromising, to some extent, the intestinal integrity, increase the gut permeability and selective translocation of Gram-positive bacteria in secondary lymphoid organs. There, anticommensal pathogenic Th17 T-cell responses are primed, facilitating the accumulation of Th1 helper T cells in tumor beds after chemotherapy as well as tumor regression. Importantly, the redox equilibrium of myeloid cells contained in the tumor microenvironment is also influenced by the intestinal microbiota. Hence, the anticancer efficacy of alkylating agents (such as cyclophosphamide) and platinum salts (oxaliplatin, cis-platin) is compromised in germ-free mice or animals treated with antibiotics. These findings represent a paradigm shift in our understanding of the mode of action of many compounds having an impact on the host-microbe mutualism.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Non spécifiée

Vulgarisation :

Non

Projet ANR :

Alliance Parisienne des Instituts de Recherche en Cancérologie

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL