Titre :

Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.

Auteur(s) :

Beltran, Sophie [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Laboratoire Écologie, Évolution, Symbiose [UMR 6556 – Poitiers] [LEES]
Gourbal, Benjamin [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Boissier, Jérôme [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Duval, David [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Kieffer-Jaquinod, S. [Auteur]
Institut de Biosciences et de Biotechnologies de Grenoble (ex-IRTSV) [BIG]
Pierce, R. J. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Grunau, Christoph [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Théron, A. [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Mitta, G. [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]

Titre de la revue :

Journal of Evolutionary Biology

Pagination :

554-72

Éditeur :

Wiley

Date de publication :

2011-03

ISSN :

1010-061X

Discipline(s) HAL :

Sciences de l'environnement/Biodiversité et Ecologie

Résumé en anglais : [en]

Schistosomes are gonochoric blood parasites with a complex life cycle responsible for a disease of considerable medical and veterinary importance in tropical and subtropical regions. Understanding the evolution of schistosome ...
Lire la suite >Schistosomes are gonochoric blood parasites with a complex life cycle responsible for a disease of considerable medical and veterinary importance in tropical and subtropical regions. Understanding the evolution of schistosome genetic diversity is clearly of fundamental importance to interpreting schistosomiasis epidemiology and disease transmission patterns of this parasite. In this article, we investigated the putative role of the host immune system in the selection of male genetic diversity. We demonstrated the link between genetic dissimilarity and the protective effect among male worms. We then compared the proteomes of three male clones with different genotypes and differing by their capacity to protect against reinfection. The identified differences correspond mainly to antigens known or supposed to be involved in the induction of protective immunity. These results underline the role played by host immune system in the selection of schistosome genetic diversity that is linked to antigenic diversity. We discuss the evolutionary consequences in the context of schistosome infection.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL