Title :

Lumen areas and homothety factor influence airway resistance in COPD.

Author(s) :

Bokov, Plamen [Auteur]
Mauroy, Benjamin [Auteur]
Revel, Marie-Pierre [Auteur]
Brun, Pierre-Amaury [Auteur]
Peiffer, Claudine [Auteur]
Daniel, Christel [Auteur]
Nay, Maria-Magdalena [Auteur]
Mahut, Bruno [Auteur]
Delclaux, Christophe [Auteur]

Journal title :

Respiratory Physiology and Neurobiology

Abbreviated title :

Respir Physiol Neurobiol

Volume number :

173

Pages :

1-10

Publisher :

Elsevier

Publication date :

2010-08-31

ISSN :

1569-9048

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire

English abstract : [en]

The remodelling process of COPD may affect both airway calibre and the homothety factor, which is a constant parameter describing the reduction of airway lumen (h(d): diameter of child\/parent bronchus) that might be ...
Show more >The remodelling process of COPD may affect both airway calibre and the homothety factor, which is a constant parameter describing the reduction of airway lumen (h(d): diameter of child\/parent bronchus) that might be critical because its reduction would induce a frank increase in airway resistance. Airway dimensions were obtained from CT scan images of smokers with (n=22) and without COPD (n=9), and airway resistance from plethysmography. Inspiratory airway resistance correlated to lumen area of the sixth bronchial generation of right lung, while peak expiratory flow correlated to the area of the third right generation (p=0.0009, R=0.57). A significant relationship was observed between h(d) and resistance (p=0.036; R(2)=0.14). A modelling approach of central airways (5 generations) further described the latter relationship. In conclusion, a constant homothety factor can be described by CT scan analysis, which partially explains inspiratory resistance, as predicted by theoretical arguments. Airway resistance is related to lumen areas of less proximal airways than commonly admitted.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2020-06-08T14:10:40Z
2021-05-14T13:22:21Z