Managing Atypical and Typical herpetic ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Managing Atypical and Typical herpetic central nervous system infections: results of A Multinational study
Author(s) :
Cag, Yasemin [Auteur]
Erdem, Hakan [Auteur]
Leib, Stephen [Auteur]
Defres, Sylviane [Auteur]
Kaya, Selcuk [Auteur]
Larsen, Lykke [Auteur]
Poljak, Mario [Auteur]
Ozturk-Engin, Derya [Auteur]
Barsic, Bruno [Auteur]
Argemi, Xavier [Auteur]
Sørensen, Signe Maj [Auteur]
Bohr, Anne Lisbeth [Auteur]
Tattevin, Pierre [Auteur]
Gunst, Jesper Damsgaard [Auteur]
Baštáková, Lenka [Auteur]
Jereb, Matjaž [Auteur]
Johansen, Isik Somuncu [Auteur]
Karabay, Oguz [Auteur]
Pekok, Abdullah Umut [Auteur]
Sipahi, Oguz Resat [Auteur]
Chehri, Mahtab [Auteur]
Béraud, Guillaume [Auteur]
Shehata, Ghaydaa [Auteur]
Fontana, Rosa [Auteur]
Maresca, Mauro [Auteur]
Karsen, Hasan [Auteur]
Sengoz, Gonul [Auteur]
Sunbul, Mustafa [Auteur]
Yilmaz, Gulden [Auteur]
Yilmaz, Hava [Auteur]
Sharif-Yakan, Ahmad [Auteur]
Kanj, Souha [Auteur]
Parlak, Emine [Auteur]
Pehlivanoglu, Filiz [Auteur]
Korkmaz, Fatime [Auteur]
Komur, Suheyla [Auteur]
Kose, Sukran [Auteur]
Ulug, Mehmet [Auteur]
Bolukcu, Sibel [Auteur]
Coskuner, Seher Ayten [Auteur]
Stahl, Jean Paul [Auteur]
Ince, Nevin [Auteur]
Akkoyunlu, Yasemin [Auteur]
Halac, Gulistan [Auteur]
Sahin-Horasan, Elif [Auteur]
Tireli, Hulya [Auteur]
Kilicoglu, Gamze [Auteur]
Al- Mahdawi, Akram [Auteur]
Nemli, Salih Atakan [Auteur]
Inan, Asuman [Auteur]
Senbayrak, Seniha [Auteur]
Vahaboglu, Haluk [Auteur]
Elaldi, Nazif [Auteur]
Erdem, Hakan [Auteur]
Leib, Stephen [Auteur]
Defres, Sylviane [Auteur]
Kaya, Selcuk [Auteur]
Larsen, Lykke [Auteur]
Poljak, Mario [Auteur]
Ozturk-Engin, Derya [Auteur]
Barsic, Bruno [Auteur]
Argemi, Xavier [Auteur]
Sørensen, Signe Maj [Auteur]
Bohr, Anne Lisbeth [Auteur]
Tattevin, Pierre [Auteur]
Gunst, Jesper Damsgaard [Auteur]
Baštáková, Lenka [Auteur]
Jereb, Matjaž [Auteur]
Johansen, Isik Somuncu [Auteur]
Karabay, Oguz [Auteur]
Pekok, Abdullah Umut [Auteur]
Sipahi, Oguz Resat [Auteur]
Chehri, Mahtab [Auteur]
Béraud, Guillaume [Auteur]
Shehata, Ghaydaa [Auteur]
Fontana, Rosa [Auteur]
Maresca, Mauro [Auteur]
Karsen, Hasan [Auteur]
Sengoz, Gonul [Auteur]
Sunbul, Mustafa [Auteur]
Yilmaz, Gulden [Auteur]
Yilmaz, Hava [Auteur]
Sharif-Yakan, Ahmad [Auteur]
Kanj, Souha [Auteur]
Parlak, Emine [Auteur]
Pehlivanoglu, Filiz [Auteur]
Korkmaz, Fatime [Auteur]
Komur, Suheyla [Auteur]
Kose, Sukran [Auteur]
Ulug, Mehmet [Auteur]
Bolukcu, Sibel [Auteur]
Coskuner, Seher Ayten [Auteur]
Stahl, Jean Paul [Auteur]
Ince, Nevin [Auteur]
Akkoyunlu, Yasemin [Auteur]
Halac, Gulistan [Auteur]
Sahin-Horasan, Elif [Auteur]
Tireli, Hulya [Auteur]
Kilicoglu, Gamze [Auteur]
Al- Mahdawi, Akram [Auteur]
Nemli, Salih Atakan [Auteur]
Inan, Asuman [Auteur]
Senbayrak, Seniha [Auteur]
Vahaboglu, Haluk [Auteur]
Elaldi, Nazif [Auteur]
Journal title :
Clinical Microbiology and Infection
Abbreviated title :
Clin Microbiol Infect
Volume number :
22
Pages :
568.e9–568.e17
Publisher :
Elsevier for the European Society of Clinical Microbiology and Infectious Diseases
Publication date :
2016-06
ISSN :
1198-743X
Keyword(s) :
Managing
Herpes simplex virus
Encephalitis
Atypical presentation
Meningitis
Herpes simplex virus
Encephalitis
Atypical presentation
Meningitis
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
There have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focused on virologically unconfirmed cases or included only small sample sizes. We have conducted ...
Show more >There have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focused on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70.8%), HSV-2 DNA in 83 patients (16.7%) and undefined HSV-DNA type in 62 patients (12.5%). A total of 379 patients (76.4%) had at least one of the specified characteristics of encephalitis, and we placed these patients into the encephalitis presentation group. The remaining 117 patients (23.6%) had none of these findings, and these patients were placed in the non-encephalitis presentation group. Abnormalities suggestive of encephalitis were detected in magnetic resonance imaging (MRI) in 83.9% of the patients and in electroencephalography (EEG) in 91.0% of patients in the encephalitis presentation group. In the non-encephalitis presentation group, MRI and EEG data were suggestive of encephalitis in 33.3% and 61.9% of patients, respectively. However, the concomitant use of MRI and EEG indicated encephalitis in 96.3% and 87.5% of the cases with and without encephalitic clinical presentation, respectively. CSF HSV-PCR, EEG and MRI data should be collected for all patients with a central nervous system infection considering the subtle nature of HMEShow less >
Show more >There have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focused on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70.8%), HSV-2 DNA in 83 patients (16.7%) and undefined HSV-DNA type in 62 patients (12.5%). A total of 379 patients (76.4%) had at least one of the specified characteristics of encephalitis, and we placed these patients into the encephalitis presentation group. The remaining 117 patients (23.6%) had none of these findings, and these patients were placed in the non-encephalitis presentation group. Abnormalities suggestive of encephalitis were detected in magnetic resonance imaging (MRI) in 83.9% of the patients and in electroencephalography (EEG) in 91.0% of patients in the encephalitis presentation group. In the non-encephalitis presentation group, MRI and EEG data were suggestive of encephalitis in 33.3% and 61.9% of patients, respectively. However, the concomitant use of MRI and EEG indicated encephalitis in 96.3% and 87.5% of the cases with and without encephalitic clinical presentation, respectively. CSF HSV-PCR, EEG and MRI data should be collected for all patients with a central nervous system infection considering the subtle nature of HMEShow less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Submission date :
2020-06-08T14:10:56Z