Titre :

Long-term Outcome After First Intestinal Resection in Pediatric-onset Crohnʼs Disease

Auteur(s) :

Boualit, Médina [Auteur]
Salleron, Julia [Auteur]
Turck, Dominique [Auteur]
Fumery, Mathurin [Auteur]
Savoye, Guillaume [Auteur]
Dupas, Jean-Louis [Auteur]
Lerebours, Eric [Auteur]
Duhamel, Alain [Auteur]
Merle, Veronique [Auteur]
Cortot, Antoine [Auteur]
Colombel, Jean-Frédéric [Auteur]
Peyrin-Biroulet, Laurent [Auteur]
Gower, Corinne [Auteur]

Titre de la revue :

Inflammatory Bowel Diseases

Nom court de la revue :

Inflamm Bowel Dis

Numéro :

19

Pagination :

7-14

Éditeur :

Lippincott, Williams & Wilkins

Date de publication :

2013

ISSN :

1078-0998

Mot(s)-clé(s) :

Pediatric Crohn's disease
CD outcome
CD surgery

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background To describe long-term postoperative evolution of pediatric-onset Crohn's disease (CD) and identify predictors of outcome we studied a population-based cohort (1988\u20132004) of 404 patients (0\u201317 years), ...
Lire la suite >Background To describe long-term postoperative evolution of pediatric-onset Crohn's disease (CD) and identify predictors of outcome we studied a population-based cohort (1988\u20132004) of 404 patients (0\u201317 years), of which 130 underwent surgery. Methods Risks for a second resection and first need for immunosuppressors (IS) and\/or biologics were estimated by survival analysis and Cox models used to determine predictors of outcome. Impact of time of first surgery on nutritional catch-up was studied using regression. Results In all, 130 patients (70 females) with a median age at diagnosis of 14.2 years (interquartile range: 12\u201316) were followed for 13 years (9.4\u201316.6). Probability of a second resection was 8%, 17%, and 29% at 2, 5, and 10 years, respectively. In multivariate analysis, age <14, stenosing (B2) and penetrating (B3) behaviors and upper gastrointestinal location (L4) at diagnosis were associated with an increased risk of second resection. Probability of receiving IS or biologics was 18%, 34%, and 47% at 2, 5, and 10 years, respectively. In multivariate analysis, L4 was a risk factor for requiring IS or biologics, while surgery within 3 years after CD diagnosis was protective. Catch-up in height and weight was better in patients who underwent surgery within 3 years after CD diagnosis than those operated on later. Conclusions In this pediatric-onset CD study, mostly performed in a prebiologic era, a first surgery performed within 3 years after CD diagnosis was associated with a reduced need for IS and biologics and a better catch-up in height and weight compared to later surgery.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2020-06-08T14:11:06Z
2021-06-02T08:49:52Z