Title :

Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis

Author(s) :

Bernardini, Michela [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Università degli studi di Torino = University of Turin [UNITO]
Brossa, Alessia [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Chinigo, Giorgia [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Grolez, Guillaume [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Trimaglio, Giulia [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Allart, Laurent [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Hulot, Audrey [Auteur]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Marot, Guillemette [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Genova, Tullio [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Joshi, Aditi [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Mattot, Virginie [Auteur]
Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161
Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]
Fromont, Gaëlle [Auteur]
Niche, Nutrition, Cancer et métabolisme oxydatif [N2Cox]
Munaron, Luca [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Bussolati, Benedetta [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Prevarskaya, Natalia [Auteur]
Physiologie Cellulaire (PHYCELL) - U1003
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Fiorio Pla, Alessandra [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Gkika, Dimitra [Auteur]
Physiologie Cellulaire (PHYCELL) - U1003
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]

Journal title :

Cancers

Volume number :

11

Pages :

956

Publisher :

MDPI

Publication date :

2019-07

ISSN :

2072-6694

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and ...
Show more >Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and tumor angiogenesis. Nonetheless, a complete TRP expression signature in tumor vessels, including in prostate cancer (PCa), is still lacking. Methods: In the present study, we profiled by qPCR the expression of all TRP channels in human prostate tumor-derived ECs (TECs) in comparison with TECs from breast and renal tumors. We further functionally characterized the role of the \u2018prostate-associated' channels in proliferation, sprout formation and elongation, directed motility guiding, as well as in vitro and in vivo morphogenesis and angiogenesis. Results: We identified three \u2018prostate-associated' genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. Conclusions: We provide here the full TRP signature of PCa vascularization among which three play a profound effect on EC biology. These results contribute to explain the aggressive phenotype previously observed in PTEC and provide new putative therapeutic targets.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2020-06-08T14:11:34Z
2022-11-16T10:56:41Z