Transient Receptor Potential Channel ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis
Auteur(s) :
Bernardini, Michela [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Brossa, Alessia [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Chinigo, Giorgia [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Grolez, Guillaume [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Trimaglio, Giulia [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Allart, Laurent [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Hulot, Audrey [Auteur]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Marot, Guillemette [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Genova, Tullio [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Joshi, Aditi [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Mattot, Virginie [Auteur]
Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]
Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161
Fromont, Gaëlle [Auteur]
Niche, Nutrition, Cancer et métabolisme oxydatif [N2Cox]
Munaron, Luca [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Bussolati, Benedetta [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Prevarskaya, Natalia [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Physiologie Cellulaire (PHYCELL) - U1003
Fiorio Pla, Alessandra [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Gkika, Dimitra [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Physiologie Cellulaire (PHYCELL) - U1003
Università degli studi di Torino = University of Turin [UNITO]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Brossa, Alessia [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Chinigo, Giorgia [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Grolez, Guillaume [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Trimaglio, Giulia [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Allart, Laurent [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Hulot, Audrey [Auteur]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Marot, Guillemette [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Genova, Tullio [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Joshi, Aditi [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Mattot, Virginie [Auteur]
Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]
Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161
Fromont, Gaëlle [Auteur]
Niche, Nutrition, Cancer et métabolisme oxydatif [N2Cox]
Munaron, Luca [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Bussolati, Benedetta [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Prevarskaya, Natalia [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Physiologie Cellulaire (PHYCELL) - U1003
Fiorio Pla, Alessandra [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Gkika, Dimitra [Auteur]
Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL]
Physiologie Cellulaire (PHYCELL) - U1003
Titre de la revue :
Cancers
Numéro :
11
Pagination :
956
Éditeur :
MDPI
Date de publication :
2019-07
ISSN :
2072-6694
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Cancer
Résumé en anglais : [en]
Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and ...
Lire la suite >Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and tumor angiogenesis. Nonetheless, a complete TRP expression signature in tumor vessels, including in prostate cancer (PCa), is still lacking. Methods: In the present study, we profiled by qPCR the expression of all TRP channels in human prostate tumor-derived ECs (TECs) in comparison with TECs from breast and renal tumors. We further functionally characterized the role of the \u2018prostate-associated' channels in proliferation, sprout formation and elongation, directed motility guiding, as well as in vitro and in vivo morphogenesis and angiogenesis. Results: We identified three \u2018prostate-associated' genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. Conclusions: We provide here the full TRP signature of PCa vascularization among which three play a profound effect on EC biology. These results contribute to explain the aggressive phenotype previously observed in PTEC and provide new putative therapeutic targets.Lire moins >
Lire la suite >Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and tumor angiogenesis. Nonetheless, a complete TRP expression signature in tumor vessels, including in prostate cancer (PCa), is still lacking. Methods: In the present study, we profiled by qPCR the expression of all TRP channels in human prostate tumor-derived ECs (TECs) in comparison with TECs from breast and renal tumors. We further functionally characterized the role of the \u2018prostate-associated' channels in proliferation, sprout formation and elongation, directed motility guiding, as well as in vitro and in vivo morphogenesis and angiogenesis. Results: We identified three \u2018prostate-associated' genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. Conclusions: We provide here the full TRP signature of PCa vascularization among which three play a profound effect on EC biology. These results contribute to explain the aggressive phenotype previously observed in PTEC and provide new putative therapeutic targets.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Date de dépôt :
2020-06-08T14:11:34Z
2022-11-16T10:56:41Z
2022-11-16T10:56:41Z
Fichiers
- cancers-11-00956-v2.pdf
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