The neural correlates of the visual ...
Document type :
Article dans une revue scientifique: Article original
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Title :
The neural correlates of the visual consciousness in schizophrenia: an fMRI study.
Author(s) :
Lefebvre, Stéphanie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Very, E [Auteur]
Toulouse NeuroImaging Center [ToNIC]
Jardri, Renaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Horn, Mathilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Yrondi, Antoine [Auteur]
Toulouse NeuroImaging Center [ToNIC]
Delmaire, Christine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Rascle, C [Auteur]
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Thomas, Pierre [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pins, Delphine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Very, E [Auteur]
Toulouse NeuroImaging Center [ToNIC]
Jardri, Renaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Horn, Mathilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Yrondi, Antoine [Auteur]
Toulouse NeuroImaging Center [ToNIC]
Delmaire, Christine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Rascle, C [Auteur]
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Thomas, Pierre [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pins, Delphine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Journal title :
European Archives of Psychiatry and Clinical Neuroscience
Abbreviated title :
Eur Arch Psychiatry Clin Neurosci
Publisher :
Springer
Publication date :
2020-08-19
Article status :
Publié
ISSN :
1433-8491
English keyword(s) :
Anterior cingulate cortex
Conscious visual processing
Consciousness disorder
Schizophrenia
Unconscious visual processing
fMRI
Conscious visual processing
Consciousness disorder
Schizophrenia
Unconscious visual processing
fMRI
HAL domain(s) :
Sciences cognitives/Neurosciences
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentale
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentale
English abstract : [en]
In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, ...
Show more >In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, when the second model suggests that consciousness disorders rely on disruption in the ability to consciously access information, with preserved unconscious processing. The current study aims to understand the mechanisms associated with visual consciousness disorder in order to pave the road that will settle the debate regarding these hypotheses. During a functional magnetic resonance imaging session, 19 healthy participants (HC) and 15 patients with schizophrenia (SCZ) performed a visual detection task to compare the neural substrates associated with the conscious access to the visual inputs. The visual detection threshold was significantly higher in SCZ than in HC [t(32) = 3.37, p = 0.002]. Whole-brain ANOVA demonstrated that around the visual detection threshold patients with SCZ failed to activate a large network of brain areas compared to HC. (1) During conscious vision, HC engaged more the left cuneus and the right occipital cortex than patients with SCZ, (2) during unconscious vision, HC engaged a large network that patients with SCZ failed to activate, and finally, (3) during the access to consciousness process, patients with SCZ failed to activate the anterior cingulate cortex. These results suggest that the consciousness disorders in schizophrenia rely on specific dysfunctions depending on the consciousness stage. The disorders of the conscious vision are associated with dysfunction of occipital areas while the ones associated with unconscious vision rely on a large widespread network. Finally, the conscious access to the visual inputs is impaired by a dysfunction of the anterior cingulate cortex. The current study suggests that none of the two suggested models can explain consciousness disorders in schizophrenia. We suggest that there is an alternative model supporting that the conscious access to visual inputs is due to a disengagement of the supragenual anterior cingulate during the unconscious processing of the visual inputs associated with a sensory deficit.Show less >
Show more >In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, when the second model suggests that consciousness disorders rely on disruption in the ability to consciously access information, with preserved unconscious processing. The current study aims to understand the mechanisms associated with visual consciousness disorder in order to pave the road that will settle the debate regarding these hypotheses. During a functional magnetic resonance imaging session, 19 healthy participants (HC) and 15 patients with schizophrenia (SCZ) performed a visual detection task to compare the neural substrates associated with the conscious access to the visual inputs. The visual detection threshold was significantly higher in SCZ than in HC [t(32) = 3.37, p = 0.002]. Whole-brain ANOVA demonstrated that around the visual detection threshold patients with SCZ failed to activate a large network of brain areas compared to HC. (1) During conscious vision, HC engaged more the left cuneus and the right occipital cortex than patients with SCZ, (2) during unconscious vision, HC engaged a large network that patients with SCZ failed to activate, and finally, (3) during the access to consciousness process, patients with SCZ failed to activate the anterior cingulate cortex. These results suggest that the consciousness disorders in schizophrenia rely on specific dysfunctions depending on the consciousness stage. The disorders of the conscious vision are associated with dysfunction of occipital areas while the ones associated with unconscious vision rely on a large widespread network. Finally, the conscious access to the visual inputs is impaired by a dysfunction of the anterior cingulate cortex. The current study suggests that none of the two suggested models can explain consciousness disorders in schizophrenia. We suggest that there is an alternative model supporting that the conscious access to visual inputs is due to a disengagement of the supragenual anterior cingulate during the unconscious processing of the visual inputs associated with a sensory deficit.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Research team(s) :
Plasticity and Subjectivity (PSY)
Troubles cognitifs dégénératifs et vasculaires
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2020-10-02T10:55:51Z
2020-10-03T09:23:49Z
2020-10-03T16:48:54Z
2020-10-22T07:09:00Z
2020-11-13T14:53:12Z
2020-12-14T08:19:55Z
2020-10-03T09:23:49Z
2020-10-03T16:48:54Z
2020-10-22T07:09:00Z
2020-11-13T14:53:12Z
2020-12-14T08:19:55Z
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