Title :

What can we learn from fMRI capture of visual hallucinations in Parkinson’s disease?

Author(s) :

Dujardin, Kathy [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Roman, David [Auteur]
Baille, Guillaume [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Pins, Delphine [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 [SCALab]
415060|||Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Lefebvre, Stéphanie [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Delmaire, Christine [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
DEFEBVRE, Luc [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Jardri, Renaud [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
415060|||Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]

Journal title :

Brain Imaging and Behavior

Abbreviated title :

Brain Imaging and Behavior

Volume number :

14

Pages :

329-335

Publisher :

Springer Science and Business Media LLC

Publication date :

2019-08-23

Article status :

Publié

English keyword(s) :

hallucination capture
two-step method
default-mode network
connectivity

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentale
Sciences cognitives/Neurosciences
Sciences cognitives/Neurosciences

English abstract : [en]

Background: With disease progression, patients with Parkinson’s disease (PD) may have chronic visual hallucinations (VH). The mechanisms behind this invalidating non-motor symptom remain largely unknown, namely because ...
Show more >Background: With disease progression, patients with Parkinson’s disease (PD) may have chronic visual hallucinations (VH). The mechanisms behind this invalidating non-motor symptom remain largely unknown, namely because it is extremely difficult to capture hallucination events. This study aimed to describe the patterns of brain functional changes when VH occur in PD patients. Methods: Nine PD patients were enrolled because of their frequent and chronic VH (> 10/day). Patients with severe cognitive decline (MMSE<18) were excluded. Patients were scanned during ON/OFF hallucinatory states and resting-state functional imaging (rs-fMRI) was performed. Data were analyzed in reference to the two-step method, which consists in: (i) a data-driven analysis of per-hallucinatory fMRI data, and (ii) selection of the components of interest based on a post-fMRI interview. Results: The phenomenology of VH ranged from visual spots to distorting faces. First, at the individual level, several VH-related components of interest were identified and integrated in a second-level analysis. Using a random-effects self-organizing-group ICA, we evidenced increased connectivity in visual networks concomitant to VH, encompassing V2, V3 and the fusiform gyri bilaterally. Interestingly, the stability of the default-mode network (DMN) was found positively correlated with VH severity (spearman’s rho = 0.77, p = 0.05). Conclusion: By using a method that does not need online self-report, we showed that VH in PD patients were associated with functional changes in associative visual cortices, possibly linked with strengthened stability of resting-state networks.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Plasticity and Subjectivity (PSY)
Troubles cognitifs dégénératifs et vasculaires

Submission date :

2020-10-03T09:21:26Z
2020-10-03T09:27:36Z
2020-12-11T08:07:15Z
2023-06-05T12:24:27Z