Title :

Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree

Author(s) :

Malfait, Benjamin [Auteur]
Institut de Physique de Rennes [IPR]
Unité Matériaux et Transformations - UMR 8207 [UMET]
T. Correia, Natália [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Ciotonea, Carmen [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Dhainaut, Jeremy [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Dacquin, Jean-Philippe [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
royer, sebastien [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Guinet, Yannick [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Hedoux, Alain [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

The Journal of Chemical Physics

Abbreviated title :

J. Chem. Phys.

Volume number :

153

Pages :

154506

Publisher :

AIP Publishing

Publication date :

2020-10-21

ISSN :

1089-7690

English keyword(s) :

Amorphous materials
Bioavailability
Mesoporous material
Nanomarterials
Dug delivery
Thermogravimetric analysis
Glass transitions
Raman spectral imaging
Differential scanning calorimetry
Nanocrystals

HAL domain(s) :

Chimie/Catalyse
Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]

English abstract : [en]

Using the Milling-Assisted Loading (MAL) solid-state method for loading a poorly water-soluble drug (ibuprofen, IBP) within the SBA-15 matrix has given the opportunity to manipulate the physical state of drugs for optimizing ...
Show more >Using the Milling-Assisted Loading (MAL) solid-state method for loading a poorly water-soluble drug (ibuprofen, IBP) within the SBA-15 matrix has given the opportunity to manipulate the physical state of drugs for optimizing bioavailability. The MAL method makes it easy to control and analyze the influence of the degree of loading on the physical state of IBP inside the SBA-15 matrix with an average pore diameter of 9.4 nm. It was found that the density of IBP molecules in an average pore size has a direct influence on both the glass transition and the mechanism of crystallization. Detailed analyzes of the crystallite distribution and melting by Raman mapping, x-ray diffraction, and differential scanning calorimetry have shown that the crystals are localized in the core of the channel and surrounded by a liquid monolayer. The results of these complementary investigations have been used for determining the relevant parameters (related to the SBA-15 matrix and to the IBP molecule) and the nature of the physical state of the confined matter.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux pour la catalyse (MATCAT)
Ingénierie des Systèmes Polymères
Matériaux Moléculaires et Thérapeutiques

Submission date :

2020-10-19T11:54:35Z
2020-10-21T14:02:34Z
2021-02-12T14:30:51Z
2022-03-24T13:18:09Z
2022-03-24T13:20:59Z