3D printed bioceramic for phage therapy against bone nosocomial infections

Bouchart, Franck; Vidal, Olivier; Lacroix, Jean-Marie; Spriet, Corentin; Chamary, Shaan; Brutel, Annie; Hornez, Jean-Christophe

Document type :

Article dans une revue scientifique

DOI :

10.1016/j.msec.2020.110840

Permalink :

http://hdl.handle.net/20.500.12210/33803

Title :

3D printed bioceramic for phage therapy against bone nosocomial infections

Author(s) :

Bouchart, Franck [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Laboratoire des Matériaux Céramiques et Procédés Associés - EA 2443 [LMCPA]
Vidal, Olivier [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Lacroix, Jean-Marie [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Spriet, Corentin [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Chamary, Shaan [Auteur]
Laboratoire des Matériaux Céramiques et Procédés Associés - EA 2443 [LMCPA]
Brutel, Annie [Auteur]
Laboratoire des Matériaux Céramiques et Procédés Associés - EA 2443 [LMCPA]
Hornez, Jean-Christophe [Auteur]
Laboratoire des Matériaux Céramiques et Procédés Associés - EA 2443 [LMCPA]

Journal title :

Materials Science and Engineering: C

Volume number :

111

Pages :

110840

Publisher :

Elsevier BV

Publication date :

2020-06

ISSN :

0928-4931

English keyword(s) :

Biomaterials
β-Tricalcium phosphate
Phage therapy
Anti-infectious
Proliferation
Biofilm

HAL domain(s) :

Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique

English abstract : [en]

This study provides a new therapeutic response to postoperative joint and bone infections. Alone or in combination with antibiotics, phage therapy has many advantages, including accurate targeting of pathogenic bacteria. ...
Show more >This study provides a new therapeutic response to postoperative joint and bone infections. Alone or in combination with antibiotics, phage therapy has many advantages, including accurate targeting of pathogenic bacteria. In addition, a decrease in harmful side effects can improve the healing process. Integrating the bacteriophage directly into the graft product will improve the antibacterial spread over the site of the surgery. The phage cocktail-filled ceramics are an innovative device for localized and curative phage therapy (in prosthetic replacement surgery, for example) in bone and joint surgery. Calcium phosphate-based ceramics were synthesized and shaped by stereolithography (3D) before loading by a phage cocktail to lyse a heterospecific bacterial population. In addition, the device makes possible the protection of osteoblastic cells against Staphylococcus aureus infection during their colonization on the ceramic material and prevents the formation of biofilm on the surface of biomaterials.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS

Collections :

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Génétique des enveloppes bactériennes

Research platform(s) :

Traitement de l'image et du signal pour la biologie (TISBio)

Submission date :

2020-11-27T13:39:32Z
2020-11-27T14:40:07Z

Files

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2	20.500.12210/33803*	2020-11-27T14:19:42Z
1	20.500.12210/33803.1	2020-11-27T13:39:32Z

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3D printed bioceramic for phage therapy ...

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