Titre :

How motility can enhance mass transfer and absorption in the duodenum: Taking the structure of the villi into account

Auteur(s) :

Zhang, Yanan [Auteur]
Wu, Peng [Auteur]
Jeantet, Romain [Auteur]
Dupont, Didier [Auteur]
Delaplace, Guillaume [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Chen, Xiao Dong [Auteur]
Xiao, Jie [Auteur]

Titre de la revue :

Chemical Engineering Science

Numéro :

213

Pagination :

115406

Éditeur :

Elsevier BV

Date de publication :

2020-02-23

ISSN :

0009-2509

Mot(s)-clé(s) en anglais :

Motility
Small intestine
Villi
Mass transfer and absorption
Numerical simulation
Moving mesh method

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Ingénierie des aliments

Résumé en anglais : [en]

Given the complex motility of the intestinal wall featuring villous structure, the mechanisms by which the motility can enhance mass transfer and absorption in the small intestine have been a mystery. In this work, the ...
Lire la suite >Given the complex motility of the intestinal wall featuring villous structure, the mechanisms by which the motility can enhance mass transfer and absorption in the small intestine have been a mystery. In this work, the challenging task to couple the intestinal lumen flow and the contraction movement of the villi is tackled by a multi-physics model. The effects of motility of an entire duodenum on the mass transfer and absorption under the influence of ambient flow can be systematically explored. It is revealed that the top of the villi plays a major role in mass absorption. For a rat duodenum, the pendular movement can enhance mass transfer and absorption by up to about 72%. With the introduction of ambient flow, although the absorption amount increases, the enhancement of mass transfer by pendular activity is inhibited. Specifically, the average enhancement factor decreases sharply from ~1.35 to ~1.05.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Processus aux Interfaces et Hygiène des Matériaux (PIHM)

Date de dépôt :

2020-12-04T14:09:44Z