Definition of the Anti-inflammatory ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus
Auteur(s) :
Gressler, Markus [Auteur]
Aspergillus
Heddergott, Christoph [Auteur]
Aspergillus
N'Go, Inés C. [Auteur]
Renga, Giorgia [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Oikonomou, Vasilis [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Moretti, Silvia [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Coddeville, Bernadette [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Gaifem, Joana [Auteur]
Life and Health Sciences Research Institute [Braga] [ICVS]
Silvestre, Ricardo [Auteur]
Life and Health Sciences Research Institute [Braga] [ICVS]
Romani, Luigina [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Latgé, Jean-Paul [Auteur]
Fontaine, Thierry [Auteur]
Aspergillus
Aspergillus
Heddergott, Christoph [Auteur]
Aspergillus
N'Go, Inés C. [Auteur]
Renga, Giorgia [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Oikonomou, Vasilis [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Moretti, Silvia [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Coddeville, Bernadette [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Gaifem, Joana [Auteur]
Life and Health Sciences Research Institute [Braga] [ICVS]
Silvestre, Ricardo [Auteur]
Life and Health Sciences Research Institute [Braga] [ICVS]
Romani, Luigina [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Latgé, Jean-Paul [Auteur]
Fontaine, Thierry [Auteur]
Aspergillus
Titre de la revue :
Frontiers in Cellular and Infection Microbiology
Nom court de la revue :
Front. Cell. Infect. Microbiol.
Numéro :
9
Éditeur :
Frontiers Media SA
Date de publication :
2019-11-06
ISSN :
2235-2988
Mot(s)-clé(s) en anglais :
galactosaminogalactan
Aspergillus fumigatus
IL-Ra
anti-inflammatory response
glycodrug
Aspergillus fumigatus
IL-Ra
anti-inflammatory response
glycodrug
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced byAspergillus fumigatusand has anti-inflammatory properties. Here, the minimumglycosidic sequences required for the induction of IL-1Ra by peripheral ...
Lire la suite >Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced byAspergillus fumigatusand has anti-inflammatory properties. Here, the minimumglycosidic sequences required for the induction of IL-1Ra by peripheral bloodmononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAGto isolate soluble oligomers, we have found that the de-N-acetylation of galactosamineresidues and the size of oligomer are critical for thein vitroimmune response. A minimaloligomer size of 20 galactosamine residues is required for the anti-inflammatory responsebut the presence of galactose residues is not necessary. In aDextran sulfate inducedcolitis mouse model, a fraction of de-N-acetylated oligomers of 13<dp<20 rescueinflammatory damage like the native GAG polymer in an IL-1Ra dependent pathway. Ourresults demonstrate the therapeutic suitability of water-soluble GAG oligosaccharidesin IL-1 mediated hyper-inflammatory diseases and suggest thatα-1,4-galactosamineoligomers chemically synthesized could represent new anti-inflammatory glycodrugs.Lire moins >
Lire la suite >Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced byAspergillus fumigatusand has anti-inflammatory properties. Here, the minimumglycosidic sequences required for the induction of IL-1Ra by peripheral bloodmononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAGto isolate soluble oligomers, we have found that the de-N-acetylation of galactosamineresidues and the size of oligomer are critical for thein vitroimmune response. A minimaloligomer size of 20 galactosamine residues is required for the anti-inflammatory responsebut the presence of galactose residues is not necessary. In aDextran sulfate inducedcolitis mouse model, a fraction of de-N-acetylated oligomers of 13<dp<20 rescueinflammatory damage like the native GAG polymer in an IL-1Ra dependent pathway. Ourresults demonstrate the therapeutic suitability of water-soluble GAG oligosaccharidesin IL-1 mediated hyper-inflammatory diseases and suggest thatα-1,4-galactosamineoligomers chemically synthesized could represent new anti-inflammatory glycodrugs.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Chemical Glycobiology
Date de dépôt :
2020-12-07T12:35:58Z
2020-12-07T16:55:16Z
2020-12-07T16:55:16Z
Fichiers
- P19.09 article oligo aspergillus.pdf
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