Title :

The role of circular folds in mixing intensification in the small intestine: A numerical study

Author(s) :

Zha, Jinping [Auteur]
Zou, Siyu [Auteur]
Hao, Jianyu [Auteur]
Liu, Xinjuan [Auteur]
Delaplace, Guillaume [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Jeantet, Romain [Auteur]
Dupont, Didier [Auteur]
Wu, Peng [Auteur]
Dong Chen, Xiao [Auteur]
Xiao, Jie [Auteur]

Journal title :

Chemical Engineering Science

Abbreviated title :

Chemical Engineering Science

Volume number :

229

Pages :

116079

Publisher :

Elsevier BV

Publication date :

2021-01-16

ISSN :

0009-2509

English keyword(s) :

Small intestine
Circular folds/Plicae circularis
Segmentation
Mixing
Process intensification
Soft elastic reactor (SER)

HAL domain(s) :

Sciences du Vivant [q-bio]/Ingénierie des aliments

English abstract : [en]

The inner wall of the intestine has multiscale structures whose roles, beyond the increase of surface area for absorption, are yet to be discovered. In this study, the mixing process in a human duodenum with circular folds, ...
Show more >The inner wall of the intestine has multiscale structures whose roles, beyond the increase of surface area for absorption, are yet to be discovered. In this study, the mixing process in a human duodenum with circular folds, driven by segmentation contraction, was simulated using a multiphysics model, making it possible to track the evolution of mixing level distributions and enabling quantitative evaluation of the structural role of folds in mixing intensification. It was found that, in a laminar flow regime, circular folds intensify both radial and axial mixing by synergistically offering prominent and long-lasting swirls/vortices, high fluid velocity and high shear rates. Tall and slim folds with enlarged segmentation amplitude, frequency and wavelength can enhance mixing. The maximum enhancement ratio can reach 6.18 under the investigated conditions. These findings will also be valuable for the improved design of biomimetic soft-elastic reactors for the chemical and pharmaceutical industries.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Processus aux Interfaces et Hygiène des Matériaux (PIHM)

Submission date :

2020-12-10T11:26:43Z