Titre :

The role of circular folds in mixing intensification in the small intestine: A numerical study

Auteur(s) :

Zha, Jinping [Auteur]
Zou, Siyu [Auteur]
Hao, Jianyu [Auteur]
Liu, Xinjuan [Auteur]
Delaplace, Guillaume [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Jeantet, Romain [Auteur]
Dupont, Didier [Auteur]
Wu, Peng [Auteur]
Dong Chen, Xiao [Auteur]
Xiao, Jie [Auteur]

Titre de la revue :

Chemical Engineering Science

Nom court de la revue :

Chemical Engineering Science

Numéro :

229

Pagination :

116079

Éditeur :

Elsevier BV

Date de publication :

2021-01-16

ISSN :

0009-2509

Mot(s)-clé(s) en anglais :

Small intestine
Circular folds/Plicae circularis
Segmentation
Mixing
Process intensification
Soft elastic reactor (SER)

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Ingénierie des aliments

Résumé en anglais : [en]

The inner wall of the intestine has multiscale structures whose roles, beyond the increase of surface area for absorption, are yet to be discovered. In this study, the mixing process in a human duodenum with circular folds, ...
Lire la suite >The inner wall of the intestine has multiscale structures whose roles, beyond the increase of surface area for absorption, are yet to be discovered. In this study, the mixing process in a human duodenum with circular folds, driven by segmentation contraction, was simulated using a multiphysics model, making it possible to track the evolution of mixing level distributions and enabling quantitative evaluation of the structural role of folds in mixing intensification. It was found that, in a laminar flow regime, circular folds intensify both radial and axial mixing by synergistically offering prominent and long-lasting swirls/vortices, high fluid velocity and high shear rates. Tall and slim folds with enlarged segmentation amplitude, frequency and wavelength can enhance mixing. The maximum enhancement ratio can reach 6.18 under the investigated conditions. These findings will also be valuable for the improved design of biomimetic soft-elastic reactors for the chemical and pharmaceutical industries.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Processus aux Interfaces et Hygiène des Matériaux (PIHM)

Date de dépôt :

2020-12-10T11:26:43Z