Title :

Niche specialization and spread of Staphylococcus capitis involved in neonatal sepsis

Author(s) :

Wirth, Thierry [Auteur correspondant]
Institut de Systématique, Evolution, Biodiversité [ISYEB ]
Bergot, Marine [Auteur]
Institut des Agents Infectieux [Lyon] [IAI]
Rasigade, Jean-Philippe [Auteur]
Institut des Agents Infectieux [Lyon] [IAI]
Institut de Systématique, Evolution, Biodiversité [ISYEB ]
Pichon, Bruno [Auteur]
Public Health England [London]
Barbier, Maxime [Auteur]
Institut de Systématique, Evolution, Biodiversité [ISYEB ]
Martins-Simoes, Patricia [Auteur]
Institut des Agents Infectieux [Lyon] [IAI]
Jacob, Laurent [Auteur]
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 [LBBE]
Pike, Rachel [Auteur]
Public Health England [London]
Tissieres, Pierre [Auteur]
AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
Institut de Biologie Intégrative de la Cellule [I2BC]
Picaud, Jean-Charles [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Kearns, Angela [Auteur]
Public Health England [London]
Supply, Philip [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Butin, Marine [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Laurent, Frederic [Auteur]
Institut des Agents Infectieux [Lyon] [IAI]
Staphylococcus Capitis Neonatal Sepsis, The International Consortium For [Auteur]
Study Group of Escmid, The Esgs [Auteur]

Journal title :

Nature Microbiology

Pages :

735-745

Publisher :

Nature Publishing Group

Publication date :

2020-04-27

ISSN :

2058-5276

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The multidrug-resistant Staphylococcus capitis NRCS-A clone is responsible for sepsis in preterm infants in neonatal intensive care units (NICUs) worldwide. Here, to retrace the spread of this clone and to identify drivers ...
Show more >The multidrug-resistant Staphylococcus capitis NRCS-A clone is responsible for sepsis in preterm infants in neonatal intensive care units (NICUs) worldwide. Here, to retrace the spread of this clone and to identify drivers of its specific success, we investigated a representative collection of 250 S. capitis isolates from adults and newborns. Bayesian analyses confirmed the spread of the NRCS-A clone and enabled us to date its emergence in the late 1960s and its expansion during the 1980s, coinciding with the establishment of NICUs and the increasing use of vancomycin in these units, respectively. This dynamic was accompanied by the acquisition of mutations in antimicrobial resistance- and bacteriocin-encoding genes. Furthermore, combined statistical tools and a genome-wide association study convergently point to vancomycin resistance as a major driver of NRCS-A success. We also identified another S. capitis subclade (alpha clade) that emerged independently, showing parallel evolution towards NICU specialization and non-susceptibility to vancomycin, indicating convergent evolution in NICU-associated pathogens. These findings illustrate how the broad use of antibiotics can repeatedly lead initially commensal drug-susceptible bacteria to evolve into multidrug-resistant clones that are able to successfully spread worldwide and become pathogenic for highly vulnerable patients.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

European Project :

Next Generation Genome Based High Resolution Tracing of Pathogens

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL