Developmental abnormalities in cortical ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors
Auteur(s) :
Imbriglio, Tiziana [Auteur]
Verhaeghe, Remy [Auteur]
Martinello, Katiuscia [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Pascarelli, Maria Teresa [Auteur]
Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS]
Chece, Giuseppina [Auteur]
Bucci, Domenico [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Notartomaso, Serena [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Quattromani, Miriana [Auteur]
Mascio, Giada [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Scalabrì, Francesco [Auteur]
Simeone, Antonio [Auteur]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Del Percio, Claudio [Auteur]
Wieloch, Tadeusz [Auteur]
Fucile, Sergio [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Babiloni, Claudio [Auteur]
Battaglia, Giuseppe [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Limatola, Cristina [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Cannella, Milena [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Verhaeghe, Remy [Auteur]
Martinello, Katiuscia [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Pascarelli, Maria Teresa [Auteur]
Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS]
Chece, Giuseppina [Auteur]
Bucci, Domenico [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Notartomaso, Serena [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Quattromani, Miriana [Auteur]
Mascio, Giada [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Scalabrì, Francesco [Auteur]
Simeone, Antonio [Auteur]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Del Percio, Claudio [Auteur]
Wieloch, Tadeusz [Auteur]
Fucile, Sergio [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Babiloni, Claudio [Auteur]
Battaglia, Giuseppe [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Limatola, Cristina [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Cannella, Milena [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Titre de la revue :
FASEB Journal
Numéro :
33
Pagination :
14204-14220
Éditeur :
Federation of American Society of Experimental Biology
Date de publication :
2019-12
Mot(s)-clé(s) en anglais :
mGlu3 receptors
cortical interneurons
development
oscillations
perineuronal nets
cortical interneurons
development
oscillations
perineuronal nets
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Polymorphic variants of the gene encoding for metabotropic glutamate receptor 3 (mGlu3) are linked to schizophrenia. Because abnormalities of cortical GABAergic interneurons lie at the core of the pathophysiology of ...
Lire la suite >Polymorphic variants of the gene encoding for metabotropic glutamate receptor 3 (mGlu3) are linked to schizophrenia. Because abnormalities of cortical GABAergic interneurons lie at the core of the pathophysiology of schizophrenia, we examined whether mGlu3 receptors influence the developmental trajectory of cortical GABAergic transmission in the postnatal life. mGlu3‐/‐ mice showed robust changes in the expression of interneuron‐related genes in the prefrontal cortex (PFC), including large reductions in the expression of parvalbumin (PV) and the GluN1 subunit of NMDA receptors. The number of cortical cells enwrapped by perineuronal nets was increased in mGlu3‐/‐ mice, suggesting that mGlu3 receptors shape the temporal window of plasticity of PV+ interneurons. Electrophysiological measurements of GABAA receptor‐mediated responses revealed a more depolarized reversal potential of GABA currents in the somata of PFC pyramidal neurons in mGlu3‐/‐ mice at postnatal d 9 associated with a reduced expression of the K+/Cl‐ symporter. Finally, adult mGlu3‐/‐ mice showed lower power in electroencephalographic rhythms at 1‐45 Hz in quiet wakefulness as compared with their wild‐type counterparts. These findings suggest that mGlu3 receptors have a strong impact on the development of cortical GABAergic transmission and cortical neural synchronization mechanisms corroborating the concept that genetic variants of mGlu3 receptors may predispose to psychiatric disorders.— Imbriglio, T., Verhaeghe, R., Martinello, K., Pascarelli, M. T., Chece, G., Bucci, D., Notartomaso, S., Quattromani, M., Mascio, G., Scalabrì, F., Simeone, A., Maccari, S., Del Percio, C., Wieloch, T., Fucile, S., Babiloni, C., Battaglia, G., Limatola, C., Nicoletti, F., Cannella, M. Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors. FASEB J. 33, 14204‐14220 (2019). www.fasebj.orgLire moins >
Lire la suite >Polymorphic variants of the gene encoding for metabotropic glutamate receptor 3 (mGlu3) are linked to schizophrenia. Because abnormalities of cortical GABAergic interneurons lie at the core of the pathophysiology of schizophrenia, we examined whether mGlu3 receptors influence the developmental trajectory of cortical GABAergic transmission in the postnatal life. mGlu3‐/‐ mice showed robust changes in the expression of interneuron‐related genes in the prefrontal cortex (PFC), including large reductions in the expression of parvalbumin (PV) and the GluN1 subunit of NMDA receptors. The number of cortical cells enwrapped by perineuronal nets was increased in mGlu3‐/‐ mice, suggesting that mGlu3 receptors shape the temporal window of plasticity of PV+ interneurons. Electrophysiological measurements of GABAA receptor‐mediated responses revealed a more depolarized reversal potential of GABA currents in the somata of PFC pyramidal neurons in mGlu3‐/‐ mice at postnatal d 9 associated with a reduced expression of the K+/Cl‐ symporter. Finally, adult mGlu3‐/‐ mice showed lower power in electroencephalographic rhythms at 1‐45 Hz in quiet wakefulness as compared with their wild‐type counterparts. These findings suggest that mGlu3 receptors have a strong impact on the development of cortical GABAergic transmission and cortical neural synchronization mechanisms corroborating the concept that genetic variants of mGlu3 receptors may predispose to psychiatric disorders.— Imbriglio, T., Verhaeghe, R., Martinello, K., Pascarelli, M. T., Chece, G., Bucci, D., Notartomaso, S., Quattromani, M., Mascio, G., Scalabrì, F., Simeone, A., Maccari, S., Del Percio, C., Wieloch, T., Fucile, S., Babiloni, C., Battaglia, G., Limatola, C., Nicoletti, F., Cannella, M. Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors. FASEB J. 33, 14204‐14220 (2019). www.fasebj.orgLire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Glycostress
Date de dépôt :
2020-12-18T14:13:58Z
2021-01-04T09:45:45Z
2021-01-07T14:30:16Z
2021-01-04T09:45:45Z
2021-01-07T14:30:16Z
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