Title :

Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Author(s) :

Mairesse, Jérôme [Auteur]
Zinni, Manuela [Auteur]
Pansiot, Julien [Auteur]
Hassan-Abdi, Rahma [Auteur]
Demene, Charlie [Auteur]
Colella, Marina [Auteur]
Charriaut-Marlangue, Christiane [Auteur]
Rideau Batista Novais, Aline [Auteur]
Tanter, Mickael [Auteur]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Gressens, Pierre [Auteur]
Vaiman, Daniel [Auteur]
Soussi-Yanicostas, Nadia [Auteur]
Baud, Olivier [Auteur]

Journal title :

Glia

Abbreviated title :

Glia

Volume number :

67

Pages :

345-359

Publisher :

Wiley

Publication date :

2018-12-02

ISSN :

0894-1491

English keyword(s) :

microglia
oxytocin
perinatal stress
neuroprotection
myelination

HAL domain(s) :

Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique

English abstract : [en]

Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverseneurocognitive outcomes. We have previously identified early deregulation of genes controllingneuroinflammation as a putative ...
Show more >Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverseneurocognitive outcomes. We have previously identified early deregulation of genes controllingneuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the devel-oping brain. While the oxytocin system was also found to be impaired following adverse perina-tal events, its role in the modulation of neuroinflammation in the developing brain is stillunknown. We used a double-hit rat model of perinatal brain injury induced by gestational lowprotein diet (LPD) and potentiated by postnatal injections of subliminal doses of interleukin-1β(IL1β) and a zebrafish model of neuroinflammation. Effects of the treatment with carbetocin, aselective, long lasting, and brain diffusible oxytocin receptor agonist, have been assessed using acombination of histological, molecular, and functional toolsin vivoandin vitro. In the double-hitmodel, white matter inflammation, deficient myelination, and behavioral deficits have beenobserved and the oxytocin system was impaired. Early postnatal supplementation with carbeto-cin alleviated microglial activation at both transcriptional and cellular levels and provided long-term neuroprotection. The central anti-inflammatory effects of carbetocin have been shownin vivoin rat pups and in a zebrafish model of early-life neuroinflammation and reproducedin vitroon stimulated sorted primary microglial cell cultures from rats subjected to LPD. Carbeto-cin treatment was associated with beneficial effects on myelination, long-term intrinsic brainconnectivity and behavior. Targeting oxytocin signaling in the developing brain may be an effec-tive approach to prevent neuroinflammation–induced brain damage of perinatal origin.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Glycostress

Submission date :

2020-12-18T15:06:58Z
2021-01-05T15:33:33Z