Oxytocin receptor agonist reduces perinatal ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia
Auteur(s) :
Mairesse, Jérôme [Auteur]
Zinni, Manuela [Auteur]
Pansiot, Julien [Auteur]
Hassan-Abdi, Rahma [Auteur]
Demene, Charlie [Auteur]
Colella, Marina [Auteur]
Charriaut-Marlangue, Christiane [Auteur]
Rideau Batista Novais, Aline [Auteur]
Tanter, Mickael [Auteur]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Gressens, Pierre [Auteur]
Vaiman, Daniel [Auteur]
Soussi-Yanicostas, Nadia [Auteur]
Baud, Olivier [Auteur]
Zinni, Manuela [Auteur]
Pansiot, Julien [Auteur]
Hassan-Abdi, Rahma [Auteur]
Demene, Charlie [Auteur]
Colella, Marina [Auteur]
Charriaut-Marlangue, Christiane [Auteur]
Rideau Batista Novais, Aline [Auteur]
Tanter, Mickael [Auteur]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Gressens, Pierre [Auteur]
Vaiman, Daniel [Auteur]
Soussi-Yanicostas, Nadia [Auteur]
Baud, Olivier [Auteur]
Titre de la revue :
Glia
Nom court de la revue :
Glia
Numéro :
67
Pagination :
345-359
Éditeur :
Wiley
Date de publication :
2018-12-02
ISSN :
0894-1491
Mot(s)-clé(s) en anglais :
microglia
oxytocin
perinatal stress
neuroprotection
myelination
oxytocin
perinatal stress
neuroprotection
myelination
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverseneurocognitive outcomes. We have previously identified early deregulation of genes controllingneuroinflammation as a putative ...
Lire la suite >Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverseneurocognitive outcomes. We have previously identified early deregulation of genes controllingneuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the devel-oping brain. While the oxytocin system was also found to be impaired following adverse perina-tal events, its role in the modulation of neuroinflammation in the developing brain is stillunknown. We used a double-hit rat model of perinatal brain injury induced by gestational lowprotein diet (LPD) and potentiated by postnatal injections of subliminal doses of interleukin-1β(IL1β) and a zebrafish model of neuroinflammation. Effects of the treatment with carbetocin, aselective, long lasting, and brain diffusible oxytocin receptor agonist, have been assessed using acombination of histological, molecular, and functional toolsin vivoandin vitro. In the double-hitmodel, white matter inflammation, deficient myelination, and behavioral deficits have beenobserved and the oxytocin system was impaired. Early postnatal supplementation with carbeto-cin alleviated microglial activation at both transcriptional and cellular levels and provided long-term neuroprotection. The central anti-inflammatory effects of carbetocin have been shownin vivoin rat pups and in a zebrafish model of early-life neuroinflammation and reproducedin vitroon stimulated sorted primary microglial cell cultures from rats subjected to LPD. Carbeto-cin treatment was associated with beneficial effects on myelination, long-term intrinsic brainconnectivity and behavior. Targeting oxytocin signaling in the developing brain may be an effec-tive approach to prevent neuroinflammation–induced brain damage of perinatal origin.Lire moins >
Lire la suite >Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverseneurocognitive outcomes. We have previously identified early deregulation of genes controllingneuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the devel-oping brain. While the oxytocin system was also found to be impaired following adverse perina-tal events, its role in the modulation of neuroinflammation in the developing brain is stillunknown. We used a double-hit rat model of perinatal brain injury induced by gestational lowprotein diet (LPD) and potentiated by postnatal injections of subliminal doses of interleukin-1β(IL1β) and a zebrafish model of neuroinflammation. Effects of the treatment with carbetocin, aselective, long lasting, and brain diffusible oxytocin receptor agonist, have been assessed using acombination of histological, molecular, and functional toolsin vivoandin vitro. In the double-hitmodel, white matter inflammation, deficient myelination, and behavioral deficits have beenobserved and the oxytocin system was impaired. Early postnatal supplementation with carbeto-cin alleviated microglial activation at both transcriptional and cellular levels and provided long-term neuroprotection. The central anti-inflammatory effects of carbetocin have been shownin vivoin rat pups and in a zebrafish model of early-life neuroinflammation and reproducedin vitroon stimulated sorted primary microglial cell cultures from rats subjected to LPD. Carbeto-cin treatment was associated with beneficial effects on myelination, long-term intrinsic brainconnectivity and behavior. Targeting oxytocin signaling in the developing brain may be an effec-tive approach to prevent neuroinflammation–induced brain damage of perinatal origin.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Glycostress
Date de dépôt :
2020-12-18T15:06:58Z
2021-01-05T15:33:33Z
2021-01-05T15:33:33Z
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