Title :

Asymmetrical diversification of the receptor-ligand interaction controlling self-incompatibility in Arabidopsis

Author(s) :

Chantreau, Maxime [Auteur]
Poux, Celine [Auteur]
Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Lensink, Marc [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Brysbaert, Guillaume [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Vekemans, Xavier [Auteur]
Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Castric, Vincent [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]

Journal title :

eLife

Volume number :

8

Pages :

e50253

Publisher :

eLife Sciences Publications, Ltd

Publication date :

2019-11-25

ISSN :

2050-084X

HAL domain(s) :

Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique

English abstract : [en]

How two-component genetic systems accumulate evolutionary novelty and diversify in the course of evolution is a fundamental problem in evolutionary systems biology. In the Brassicaceae, self-incompatibility (SI) is a ...
Show more >How two-component genetic systems accumulate evolutionary novelty and diversify in the course of evolution is a fundamental problem in evolutionary systems biology. In the Brassicaceae, self-incompatibility (SI) is a spectacular example of a diversified allelic series in which numerous highly diverged receptor-ligand combinations are segregating in natural populations. However, the evolutionary mechanisms by which new SI specificities arise have remained elusive. Using in planta ancestral protein reconstruction, we demonstrate that two allelic variants segregating as distinct receptor-ligand combinations diverged through an asymmetrical process whereby one variant has retained the same recognition specificity as their (now extinct) putative ancestor, while the other has functionally diverged and now represents a novel specificity no longer recognized by the ancestor. Examination of the structural determinants of the shift in binding specificity suggests that qualitative rather than quantitative changes of the interaction are an important source of evolutionary novelty in this highly diversified receptor-ligand system.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

European Project :

Emergence of novel phenotypes in co-evolving biological systems: allelic diversification and dominance at the Self-incompatibility locus in Arabidopsis.

Administrative institution(s) :

Université de Lille
CNRS

Collections :

• Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Computational Molecular Systems Biology

Submission date :

2021-01-04T08:16:27Z
2021-06-10T16:27:26Z