PHOS-ISTOS: A new flexible and homogeneous device for photodynamic treatment of actinic keratosis, first clinical results

Mordon, Serge; Thecua, E.; Tylcz, J.-B.; Vicentini, C.; Mortier, L.; Szeimies, R.-M.

Document type :

Communication dans un congrès avec actes

DOI :

10.1016/j.pdpdt.2017.01.144

Title :

PHOS-ISTOS: A new flexible and homogeneous device for photodynamic treatment of actinic keratosis, first clinical results

Author(s) :

Mordon, Serge [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Thecua, E. [Auteur]
Tylcz, J.-B. [Auteur]
Vicentini, C. [Auteur]
Mortier, L. [Auteur]
Szeimies, R.-M. [Auteur]

Conference title :

IPA

City :

NANCY

Country :

France

Start date of the conference :

2016-10-24

Journal title :

Photodiagnosis and Photodynamic Therapy

Publication date :

2017-03

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

The PHOS-ISTOS device (resulting from the European project " CIP project 621103 PHOSISTOS ") based on light emitting fabric is proposed for the treatment of actinic keratosis. Actinic kerato-sis is common pre-cancerous ...
Show more >The PHOS-ISTOS device (resulting from the European project " CIP project 621103 PHOSISTOS ") based on light emitting fabric is proposed for the treatment of actinic keratosis. Actinic kerato-sis is common pre-cancerous skin lesions, which mainly affect the elderly population. Induced by sun damages, these lesions are usually present on the scalp, shoulders or arms of the patients and thus are easily reachable by light, making PDT one of the first line treatment [1]. Optical fibers are knitted to build a flexible structure that produces homogeneous light. The fabrics are embedded within an adjustable plastic helmet and illuminated by a fractionated LASER source. The low delivered irradiance (4 mW/cm 2) and the shorter photosensitizer application time ensure a significant pain reduction , compared to discomfort levels usually experienced by patients during a conventional PDT. The proposed device delivers a total light dose of 12 J/cm 2 , instead of 37 J/cm 2 which efficiency is being assessed in a bi-centric clinical trial. The first results of the clinical test (assessment of pain, patient's comfort and PDT action of the device) will be presented.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :