Title :

Stability of folic acid under several parameters

Author(s) :

Gazzali, Amirah Mohd [Auteur]
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Universiti Sains Malaysia [USM]
Lobry, mathilde [Auteur]
Laboratoire Réactions et Génie des Procédés [LRGP]
Colombeau, Ludovic [Auteur]
Laboratoire Réactions et Génie des Procédés [LRGP]
Acherar, Samir [Auteur]
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Azaïs, Henri [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Mordon, Serge [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Arnoux, Philippe [Auteur]
Laboratoire Réactions et Génie des Procédés [LRGP]
Baros, Francis [Auteur]
Laboratoire Réactions et Génie des Procédés [LRGP]
Vanderesse, Régis [Auteur]
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Frochot, Céline [Auteur]
Laboratoire Réactions et Génie des Procédés [LRGP]

Journal title :

European Journal of Pharmaceutical Sciences

Pages :

419-430

Publisher :

Elsevier

Publication date :

2016-10

ISSN :

0928-0987

English keyword(s) :

Folic acid degradation
p-Aminobenzoyl-L-glutamic acid
Pterin
p-Aminobenzoic acid
Photolysis
pH

HAL domain(s) :

Chimie/Chimie organique
Chimie/Polymères

English abstract : [en]

Folic acid is a small molecule, also known as vitamin B-9. It is an essential compound involved in important biochemical processes. It is widely used as a vector for targeted treatment and diagnosis especially in cancer ...
Show more >Folic acid is a small molecule, also known as vitamin B-9. It is an essential compound involved in important biochemical processes. It is widely used as a vector for targeted treatment and diagnosis especially in cancer therapeutics. Nevertheless, not many authors address the problem of folic acid degradation. Several researchers reported their observations concerning its denaturation, but they generally only took into account one parameter (pH, temperature, light or O-2 etc.). In this review, we will focus on five main parameters (assessed individually or in conjunction with one or several others) that have to be taken into account to avoid the degradation of folic acid: light, temperature, concentration, oxygen and pH, which are the most cited in the literature. Scrupulous bibliographic research enabled us to determine two additional degradation factors that are the influence of singlet oxygen and electron beam on folic acid stability, which are not considered as among the prime factors. Although these two factors are not commonly present as compared to the others, singlet oxygen and electron beams intervene in new therapeutic technologies and must be taken in consideration for further applications such photodynamic or X-rays therapies.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL