Title :

Nuclear medicine for photodynamic therapy in cancer: planning, monitoring and nuclear PDT

Author(s) :

Kharroubi Lakouas, Dris [Auteur]
Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI]
Huglo, Damien [Auteur]
Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI]
Mordon, Serge [Auteur]
Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI]
Vermandel, Maximilien [Auteur correspondant]
Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI]

Journal title :

Photodiagnosis and Photodynamic Therapy

Pages :

Epub ahead of print

Publisher :

Elsevier

Publication date :

2017

ISSN :

1572-1000

English keyword(s) :

Photodynamic therapy
Oncology
PET
SPECT
5-Aminolevulinic acid
PPIX

HAL domain(s) :

Sciences du Vivant [q-bio]/Ingénierie biomédicale/Médecine nucléaire
Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Ingénierie biomédicale

English abstract : [en]

Photodynamic therapy (PDT) is a modality with promising results for the treatment of various cancers. PDT is increasingly included in the standard of care for different pathologies. This therapy relies on the effects of ...
Show more >Photodynamic therapy (PDT) is a modality with promising results for the treatment of various cancers. PDT is increasingly included in the standard of care for different pathologies. This therapy relies on the effects of light delivered to photosensitized cells. At different stages of delivery, PDT requires imaging toplan, evaluate and monitor treatment. The contribution of molecular imaging in this context is important and continues to increase. In this article, we review the contribution of nuclear medicine imaging in oncology to PDT for planning and therapeutic monitoring purposes. Several solutions have been proposed to plan PDT from nuclear medicine imaging. For instance, photosensitizer biodistribution has been evaluated with aradiolabeled photosensitizer or with conventionalradiopharmaceuticals on positron emission tomography. The effects of PDT delivery have also been explored with specific SPECT or PET radiopharmaceuticals to evaluate the effects on cells (apoptosis, necrosis, proliferation, metabolism) or vascular damage. Finally, the synergy between photosensitizers and radiopharmaceuticals has been studied considering the Cerenkov effect to activate photosensitized cells.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL