Maternal high-fat diet during suckling ...
Document type :
Article dans une revue scientifique: Article original
Title :
Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring
Author(s) :
Butruille, Laura [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Marousez, Lucie [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Pourpe, Charlène [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Oger, Frédérik [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Lecoutre, Simon [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Catheline, Daniel [Auteur]
Laboratoire de Biochimie et Nutrition Humaine
Görs, Solvig [Auteur]
Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere [FBN]
Metges, Cornelia [Auteur]
Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere [FBN]
Guinez, Céline [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Laborie, Christine [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Deruelle, Philippe [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Eeckhoute, Jérôme [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Breton, Christophe [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Legrand, Philippe [Auteur]
Laboratoire de Biochimie et Nutrition Humaine
Lesage, Jean [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Eberlé, Delphine [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]

Environnement périnatal et croissance - EA 4489 [EPS]
Marousez, Lucie [Auteur]

Environnement périnatal et croissance - EA 4489 [EPS]
Pourpe, Charlène [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Oger, Frédérik [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Lecoutre, Simon [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Catheline, Daniel [Auteur]
Laboratoire de Biochimie et Nutrition Humaine
Görs, Solvig [Auteur]
Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere [FBN]
Metges, Cornelia [Auteur]
Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere [FBN]
Guinez, Céline [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Laborie, Christine [Auteur]

Environnement périnatal et croissance - EA 4489 [EPS]
Deruelle, Philippe [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Eeckhoute, Jérôme [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Breton, Christophe [Auteur]

Environnement périnatal et croissance - EA 4489 [EPS]
Legrand, Philippe [Auteur]
Laboratoire de Biochimie et Nutrition Humaine
Lesage, Jean [Auteur]

Environnement périnatal et croissance - EA 4489 [EPS]
Eberlé, Delphine [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Journal title :
International Journal of Obesity
Publisher :
Nature Publishing Group
Publication date :
2019-01-08
ISSN :
0307-0565
HAL domain(s) :
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Alimentation et Nutrition
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
Sciences du Vivant [q-bio]/Alimentation et Nutrition
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
English abstract : [en]
OBJECTIVE: The lactation-suckling period is critical for white adipose tissue (WAT) development. Early postnatal nutrition influences later obesity risk but underlying mechanisms remain elusive. Here, we tested whether ...
Show more >OBJECTIVE: The lactation-suckling period is critical for white adipose tissue (WAT) development. Early postnatal nutrition influences later obesity risk but underlying mechanisms remain elusive. Here, we tested whether altered postnatal nutrition specifically during suckling impacts epigenetic regulation of key metabolic genes in WAT and alter long-term adiposity set point.METHODS:We analyzed the effects of maternal high-fat (HF) feeding in rats exclusively during lactation-suckling on breast milk composition and its impact on male offspring visceral epidydimal (eWAT) and subcutaneous inguinal (iWAT) depots during suckling and in adulthood.RESULTS:Maternal HF feeding during lactation had no effect on mothers' body weight (BW) or global breast milk composition, but induced qualitative changes in breast milk fatty acid (FA) composition (high n-6/n-3 polyunsaturated FA ratio and low medium-chain FA content). During suckling, HF neonates showed increased BW and mass of both eWAT and iWAT depot but only eWAT displayed an enhanced adipogenic transcriptional signature. In adulthood, HF offspring were predisposed to weight gain and showed increased hyperplastic growth only in eWAT. This specific eWAT expansion was associated with increased expression and activity of stearoyl-CoA desaturase-1 (SCD1), a key enzyme of FA metabolism. SCD1 converts saturated FAs, e.g. palmitate and stearate, to monounsaturated FAs, palmitoleate and oleate, which are the predominant substrates for triglyceride synthesis. Scd1 upregulation in eWAT was associated with reduced DNA methylation in Scd1 promoter surrounding a PPARγ-binding region. Conversely, changes in SCD1 levels and methylation were not observed in iWAT, coherent with a depot-specific programming.CONCLUSIONS: Our data reveal that maternal HF feeding during suckling programs long-term eWAT expansion in part by SCD1 epigenetic reprogramming. This programming events occurred with drastic changes in breast milk FA composition, suggesting that dietary FAs are key metabolic programming factors in the early postnatal period.Show less >
Show more >OBJECTIVE: The lactation-suckling period is critical for white adipose tissue (WAT) development. Early postnatal nutrition influences later obesity risk but underlying mechanisms remain elusive. Here, we tested whether altered postnatal nutrition specifically during suckling impacts epigenetic regulation of key metabolic genes in WAT and alter long-term adiposity set point.METHODS:We analyzed the effects of maternal high-fat (HF) feeding in rats exclusively during lactation-suckling on breast milk composition and its impact on male offspring visceral epidydimal (eWAT) and subcutaneous inguinal (iWAT) depots during suckling and in adulthood.RESULTS:Maternal HF feeding during lactation had no effect on mothers' body weight (BW) or global breast milk composition, but induced qualitative changes in breast milk fatty acid (FA) composition (high n-6/n-3 polyunsaturated FA ratio and low medium-chain FA content). During suckling, HF neonates showed increased BW and mass of both eWAT and iWAT depot but only eWAT displayed an enhanced adipogenic transcriptional signature. In adulthood, HF offspring were predisposed to weight gain and showed increased hyperplastic growth only in eWAT. This specific eWAT expansion was associated with increased expression and activity of stearoyl-CoA desaturase-1 (SCD1), a key enzyme of FA metabolism. SCD1 converts saturated FAs, e.g. palmitate and stearate, to monounsaturated FAs, palmitoleate and oleate, which are the predominant substrates for triglyceride synthesis. Scd1 upregulation in eWAT was associated with reduced DNA methylation in Scd1 promoter surrounding a PPARγ-binding region. Conversely, changes in SCD1 levels and methylation were not observed in iWAT, coherent with a depot-specific programming.CONCLUSIONS: Our data reveal that maternal HF feeding during suckling programs long-term eWAT expansion in part by SCD1 epigenetic reprogramming. This programming events occurred with drastic changes in breast milk FA composition, suggesting that dietary FAs are key metabolic programming factors in the early postnatal period.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Source :