Title :

Photothermally triggered on-demand insulin release from reduced graphene oxide modified hydrogels

Author(s) :

Teodorescu, Florina [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Oz, Yavuz [Auteur]
Boǧaziçi üniversitesi = Boğaziçi University [Istanbul]
Queniat, Gurvan [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Abderrahmani, Amar [Auteur]
Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 [EGENODIA (GI3M)]
Foulon, Catherine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Lecoeur, Marie [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Sanal, Rana [Auteur]
Boǧaziçi üniversitesi = Boğaziçi University [Istanbul]
Sanyal, Amitav [Auteur]
Boǧaziçi üniversitesi = Boğaziçi University [Istanbul]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]

Journal title :

Journal of Controlled Release

Pages :

164-173

Publisher :

Elsevier

Publication date :

2017

ISSN :

0168-3659

HAL domain(s) :

Chimie/Polymères
Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacie galénique

English abstract : [en]

On-demand delivery of therapeutics plays an essential role in simplifying and improving patient care. The high loading capacity of reduced graphene oxide (rGO) for drugs has made this matrix of particular interest for its ...
Show more >On-demand delivery of therapeutics plays an essential role in simplifying and improving patient care. The high loading capacity of reduced graphene oxide (rGO) for drugs has made this matrix of particular interest for its hybridization with therapeutics. In this work, we describe the formulation of rGO impregnated poly(ethylene glycol) dimethacrylate based hydrogels (PEGDMA-rGO) and their efficient loading with insulin. Near-infrared (NIR) light induced heating of the PEGDMA-rGO hydrogels allows for highly efficient insulin release. Most importantly, we validate that the NIR irradiation of the hydrogel has no effect on the biological and metabolic activities of the released insulin. The ease of insulin loading/reloading makes this photothermally triggered release strategy of interest for diabetic patients. Additionally, the rGO-based protein releasing platform fabricated here can be expanded towards 'on demand' release of various other therapeutically relevant biomolecules. Graphical abstract. The table of contents entry: Poly(ethylene glycol) based hydrogels impregnated with rGO allow efficient loading and 'on demand' photothermal release of insulin while preserving its biological and metabolic activity.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

European Project :

Pathogen and Graphene

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL