PPARbeta in macrophages and atherosclerosis
Document type :
Article dans une revue scientifique: Article original
PMID :
Title :
PPARbeta in macrophages and atherosclerosis
Author(s) :
Chinetti-Gbaguidi, Giulia [Auteur]
Institut de Recherche sur le Cancer et le Vieillissement [IRCAN]
Staels, Bart [Auteur correspondant]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Institut de Recherche sur le Cancer et le Vieillissement [IRCAN]
Staels, Bart [Auteur correspondant]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Journal title :
Biochimie
Publisher :
Elsevier
Publication date :
2017
ISSN :
0300-9084
English keyword(s) :
Atherosclerotic lesion
Gene regulation
Inflammation
Lipid metabolism
Transcription factor
Gene regulation
Inflammation
Lipid metabolism
Transcription factor
HAL domain(s) :
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
English abstract : [en]
Macrophages are central cells in the genesis and development of atherosclerosis, one of themajor causes of cardiovascular diseases. Macrophages take up lipids (mainly cholesterol andtriglycerides) from lipoproteins thus ...
Show more >Macrophages are central cells in the genesis and development of atherosclerosis, one of themajor causes of cardiovascular diseases. Macrophages take up lipids (mainly cholesterol andtriglycerides) from lipoproteins thus transforming into foam cells. Moreover, through theefflux pathway, macrophages are the main actors of the elimination of excessive tissuecholesterol toward extra-cellular acceptors. Macrophages participate in the control ofinflammation by displaying different functional phenotypes, from the M1 pro-inflammatoryto the M2 anti-inflammatory state.The nuclear receptor Peroxisome Proliferator-Activated Receptor (PPAR)beta (also calledPPARdelta or PPARbeta/delta) is expressed in macrophages where it plays a different role in the controlof lipid metabolism, inflammation and phagocytosis of apoptotic cells.This review will summarize our current understanding of how PPARbeta regulates macrophagebiology and its impact on atherosclerosis. Differences between studies and species-specificmacrophage gene regulation will be discussed.Show less >
Show more >Macrophages are central cells in the genesis and development of atherosclerosis, one of themajor causes of cardiovascular diseases. Macrophages take up lipids (mainly cholesterol andtriglycerides) from lipoproteins thus transforming into foam cells. Moreover, through theefflux pathway, macrophages are the main actors of the elimination of excessive tissuecholesterol toward extra-cellular acceptors. Macrophages participate in the control ofinflammation by displaying different functional phenotypes, from the M1 pro-inflammatoryto the M2 anti-inflammatory state.The nuclear receptor Peroxisome Proliferator-Activated Receptor (PPAR)beta (also calledPPARdelta or PPARbeta/delta) is expressed in macrophages where it plays a different role in the controlof lipid metabolism, inflammation and phagocytosis of apoptotic cells.This review will summarize our current understanding of how PPARbeta regulates macrophagebiology and its impact on atherosclerosis. Differences between studies and species-specificmacrophage gene regulation will be discussed.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Oui
ANR Project :
Source :
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