Control of nuclear receptor activities in metabolism by post-translational modifications.

Berrabah, Wahiba; Aumercier, Pierrette; Lefebvre, Philippe; Staels, Bart

Document type :

Compte-rendu et recension critique d'ouvrage

DOI :

10.1016/j.febslet.2011.03.066

PMID :

21486568

Title :

Control of nuclear receptor activities in metabolism by post-translational modifications.

Author(s) :

Berrabah, Wahiba [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Aumercier, Pierrette [Auteur]

Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Lefebvre, Philippe [Auteur]

Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Staels, Bart [Auteur correspondant]

Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]

Journal title :

Febs Letters

Pages :

1640-50

Publisher :

Wiley

Publication date :

2011-06-06

ISSN :

0014-5793

English keyword(s) :

NRs
metabolism
post-translational modifications

HAL domain(s) :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire

English abstract : [en]

Nuclear receptors (NRs) are molecular transducers of endocrine and dietary signals allowing tissues to adapt their transcriptional responses to endogenous or exogenous cues. These signals act in many cases as specific ...
Show more >Nuclear receptors (NRs) are molecular transducers of endocrine and dietary signals allowing tissues to adapt their transcriptional responses to endogenous or exogenous cues. These signals act in many cases as specific ligands, converting of NRs into transcriptionally active molecules. This on-off mechanism needs, however, to be finely tuned with respect to the tissue environment and adjusted to the organism needs. These subtle adjustments of NR transcriptional activity are brought about by post-translational modifications (PTMs), which can be, in the case of orphan NRs, the sole regulatory mechanism. The role of PTMs, with a more specific focus on phosphorylation, affecting the functions of NR controlling metabolic events is described in this review.Show less >

Language :

Anglais

Popular science :

Non

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