Title :

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

Author(s) :

Morant, Pierre-Emmanuel [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Thommen, Quentin [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Lemaire, Francois [Auteur]
Calcul Formel [CALFOR]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Vandermoëre, Constant [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Parent, Benjamin [Auteur]
Institut de Recherche Interdisciplinaire [Villeneuve d'Ascq] [IRI]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
LEFRANC, Marc [Auteur correspondant]
Institut de Recherche Interdisciplinaire [Villeneuve d'Ascq] [IRI]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]

Journal title :

Physical Review Letters

Pages :

068104

Publisher :

American Physical Society

Publication date :

2009-02-13

ISSN :

0031-9007

HAL domain(s) :

Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
Informatique [cs]/Bio-informatique [q-bio.QM]
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Réseaux moléculaires [q-bio.MN]

English abstract : [en]

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for ...
Show more >We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Comment :

Accepted for publication in Physical Review Letters.

Collections :

• Laboratoire de Physique des Lasers, Atomes et Molécules (PhLAM) - UMR 8523

Source :

Harvested from HAL