Title :

Alginate versus npwt in the preparation of surgical excisions for an stsg: atec trial

Author(s) :

Casanova, Dominique [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Guerreschi, Pierre [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Sinna, Raphael [Auteur]
CHU Amiens-Picardie
Bertheuil, Nicolas [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Philandrianos, Cecile [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Chignon-Sicard, Berengere [Auteur]
Université Côte d'Azur [UniCA]
Duteille, Franck [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Atlan, Michael [Auteur]
CHU Tenon [AP-HP]
Rousseau, Pascal [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Chatellier, Gilles [Auteur]
CIC - HEGP [CIC 1418]
Boucher, Fabien [Auteur]
Pham Dang, Nathalie [Auteur]
CHU Clermont-Ferrand
Cambon-Binder, Adeline [Auteur]
CHU Saint-Antoine [AP-HP]
Michot, Audrey [Auteur]
Pluvy, Isabelle [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Seigle-Murandi, Frederic [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Hu, Weiguo [Auteur]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Revol, Marc [Auteur]
CHU Tenon [AP-HP]

Journal title :

Plastic and Reconstructive Surgery, Global Open

Abbreviated title :

Plast Reconstr Surg Glob Open

Volume number :

8

Pages :

e2691

Publication date :

2020-03-01

ISSN :

2169-7574

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

A calcium alginate dressing (ALGINATE) and negative pressure wound therapy (NPWT) are frequently used to treat wounds which heal by secondary intention. This trial compared the healing efficacy and safety of these 2 ...
Show more >A calcium alginate dressing (ALGINATE) and negative pressure wound therapy (NPWT) are frequently used to treat wounds which heal by secondary intention. This trial compared the healing efficacy and safety of these 2 treatments. This randomized, non-inferiority trial enrolled patients who underwent skin excision (>30 cm2 ALGINATE and NPWT were applied to 47 and 48 patients, respectively. The mean time to optimal granulation was 19.98 days (95% CI, 17.7-22.3) with ALGINATE and 20.54 (95% CI, 17.6-23.5) with NPWT. Between group difference was -0.56 days (95% CI -4.22 to 3.10). The non-inferiority of ALGINATE versus NPWT was demonstrated. No AE related to the treatment occurred with ALGINATE versus 14 AEs with NPWT. There was no difference in the impact of the treatments on the patient's daily life. This trial demonstrates that ALGINATE has a similar healing efficacy to that of NPWT and that is markedly better with regard to patient safety.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Submission date :

2021-01-20T15:58:57Z
2024-02-23T08:53:54Z