Title :

Development, validation and method stability study of a lc-ms method to quantify leuprolide (hormone analog) in human plasma

Author(s) :

Skiba, Mohamed [Auteur]
Différenciation et communication neuronale et neuroendocrine [DC2N]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Fatmi, S. [Auteur]
Université de Rouen Normandie [UNIROUEN]
Université Abderrahmane Mira [Université de Béjaïa] = University Abderrahmane Mira [University of Béjaïa] [UB]
Elkasri, N. [Auteur]
Université de Rouen Normandie [UNIROUEN]
Karrout, Youness [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Lahiani-Skiba, Malika [Auteur]
Différenciation et communication neuronale et neuroendocrine [DC2N]
Université de Rouen Normandie [UNIROUEN]

Journal title :

Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences

Abbreviated title :

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.

Volume number :

1160

Pages :

122345

Publication date :

2020-08-27

ISSN :

1873-376X

English keyword(s) :

Leuprolide
LC-MS
Quantification
Validation
Solid phase micro extraction
GnRH analog
Human plasma

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

A rapid, highly sensitive and simple high-performance liquid chromatographic-tandem mass spectrometric (LC-MS) assay is developed and validated for the quantification of leuprolide: a Gonadotropin Releasing Hormone analog ...
Show more >A rapid, highly sensitive and simple high-performance liquid chromatographic-tandem mass spectrometric (LC-MS) assay is developed and validated for the quantification of leuprolide: a Gonadotropin Releasing Hormone analog (GnRH) in human plasma. Moreover, various parameters of the method stability are determined. After the addition of stable isotope (internal standard), the leuprolide was extracted from human plasma by a C181813615Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Submission date :

2021-01-20T15:59:00Z
2024-02-15T09:04:01Z