Title :

Mineralization of gellan gum hydrogels with calcium and magnesium carbonates by alternate soaking in solutions of calcium/magnesium and carbonate ion solutions

Author(s) :

Lopez, Marco [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Médicaments et Biomatériaux à libération contrôlée : Mécanismes et Optimisation - U1008
Lapa, Agata [Auteur]
AGH University of Science and Technology [Krakow, PL] [AGH UST]
Reczynska, Katarzyna [Auteur]
AGH University of Science and Technology [Krakow, PL] [AGH UST]
Pietryga, Krzysztof [Auteur]
AGH University of Science and Technology [Krakow, PL] [AGH UST]
Balcaen, Lieve [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Mendes, Ana C. [Auteur]
Danmarks Tekniske Universitet = Technical University of Denmark [DTU]
Schaubroeck, David [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Van Der Voort, Pascal [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Dokupil, Agnieszka [Auteur]
Plis, Agnieszka [Auteur]
Stevens, Chris V. [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Parakhonskiy, Bogdan V. [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Samal, Sangram Keshari [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Vanhaecke, Frank [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Chronakis, Ioannis S. [Auteur]
Danmarks Tekniske Universitet = Technical University of Denmark [DTU]
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Pamula, Elzbieta [Auteur]
AGH University of Science and Technology [Krakow, PL] [AGH UST]
Skirtach, Andre G. [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Douglas, Timothy E. L. [Auteur]
Lancaster University

Journal title :

Journal of Tissue Engineering and Regenerative Medicine

Abbreviated title :

J Tissue Eng Regen Med

Volume number :

12

Pages :

1825-1834

Publication date :

2018-04-27

ISSN :

1932-7005

Keyword(s) :

magnesium
calcium carbonate
composite
gellan gum hydrogels
mineralization

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Mineralization of hydrogels is desirable prior to applications in bone regeneration. CaCO3 is a widely used bone regeneration material, and Mg, when used as a component of calcium phosphate biomaterials, has promoted ...
Show more >Mineralization of hydrogels is desirable prior to applications in bone regeneration. CaCO3 is a widely used bone regeneration material, and Mg, when used as a component of calcium phosphate biomaterials, has promoted bone-forming cell adhesion and proliferation and bone regeneration. In this study, gellan gum hydrogels were mineralized with carbonates containing different amounts of calcium (Ca) and magnesium (Mg) by alternate soaking in, firstly, a calcium and/or magnesium ion solution and, secondly, a carbonate ion solution. This alternate soaking cycle was repeated five times. Five different calcium and/or magnesium ion solutions, containing different molar ratios of Ca to Mg ranging from Mg free to Ca free were compared. Carbonate mineral formed in all sample groups subjected to the alternate soaking cycle. Ca : Mg elemental ratio in the mineral formed was higher than in the respective mineralizing solution. Mineral formed in the absence of Mg was predominantly CaCO3 in the form of a mixture of calcite and vaterite. Increasing the Mg content in the mineral formed led to the formation of magnesian calcite and decreased the total amount of the mineral formed and its crystallinity. Hydrogel mineralization and increasing Mg content in mineral formed did not obviously improve proliferation of MC3T3-E1 osteoblast-like cells or differentiation after 7 days.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Submission date :

2021-01-20T15:59:07Z
2024-02-23T13:39:59Z