Title :

Lipids and polymers in pharmaceutical technology: lifelong companions

Author(s) :

Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Faham, Amina [Auteur]
DuPont Health & Nutrition
Clas, Sophie-Dorothee [Auteur]
Boyd, Ben J. [Auteur]
Monash Institute of Pharmaceutical Sciences [Parkville] [MIPS]
Jannin, Vincent [Auteur]
Gattefossé SAS
Bernkop-Schnurch, Andreas [Auteur]
Leopold Franzens Universität Innsbruck - University of Innsbruck
Zhao, Hang [Auteur]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Lecommandoux, Sebastien [Auteur]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Evans, James C. [Auteur]
University of Toronto
Allen, Christine [Auteur]
University of Toronto
Merkel, Olivia M. [Auteur]
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
Costabile, Gabriella [Auteur]
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
Alexander, Morgan R. [Auteur]
University of Nottingham, UK [UON]
Wildman, Ricky D. [Auteur]
University of Nottingham, UK [UON]
Roberts, Clive J. [Auteur]
University of Nottingham, UK [UON]
Leroux, Jean-Christophe [Auteur]
Institute of Pharmaceutical Sciences [ETH Zürich] [IPW]

Journal title :

International Journal of Pharmaceutics

Abbreviated title :

Int J Pharm

Volume number :

558

Pages :

128-142

Publication date :

2019-01-09

ISSN :

1873-3476

Keyword(s) :

Gene delivery
Polymersomes
Solid dispersions
Self-emulsifying drug delivery systems
Sustained release
3D printing
Liposomes
Peptides

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles ...
Show more >In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and transfection agents. Focusing on selected applications, which were discussed at the Annual Scientific Meeting of the Gattefossé Foundation 2018, this manuscript recapitulates the fundamental roles of these two important classes of excipients, either employed alone or in combination, and provides insight on their functional properties in various types of drug formulations. Emphasis is placed on oral formulations for the administration of active pharmaceutical ingredients with low aqueous solubilities or poor permeation properties. Additionally, this review article covers the use of lipids and polymers in the design of colloidal injectable delivery systems, and as substrates in additive manufacturing technologies for the production of tailor-made dosage forms.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Submission date :

2021-01-20T15:59:10Z
2024-02-23T11:11:03Z