Title :

Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application

Author(s) :

Aubert-Viard, Francois [Auteur]
Mogrovejo-Valdivia, Alejandra [Auteur]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Maton, Mickael [Auteur]
Chai, Feng [Auteur]
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]

Journal title :

Materials science & engineering. C, Materials for biological applications

Abbreviated title :

Mater Sci Eng C Mater Biol Appl

Volume number :

100

Pages :

554-563

Publication date :

2019-07-01

ISSN :

1873-0191

Keyword(s) :

Antibacterial textile
Chitosan
Layer-by-layer
Chlorhexidine
Cyclodextrin
Cytocompatibility
Genipin

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) ...
Show more >The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) (PET) of the dressing was first modified by chitosan (CHT) crosslinked with genipin (Gpn). Parameters such as the concentration of reagents (Gpn and CHT) but also the crosslinking time and the working temperature were optimized to reach the maximal positive charges surface density. This support was then treated by the layer-by-layer (LbL) deposition of a multilayer system composed of methyl-beta-cyclodextrin polymer (PCD) (anionic) and CHT (cationic). After a thermal treatment to stabilize the LbL film, the textiles were loaded with CHX as antiseptic agent. The influence of the thermal treatment i) on the cytocompatibility, ii) on the degradation of the multilayer system, iii) on CHX sorption and release profiles and iv) on the antibacterial activity of the loaded textiles was studied.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
ENSCL
INRA
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité Matériaux et Transformations (UMET) - UMR 8207

Submission date :

2021-01-20T15:59:12Z