Titre :

Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application

Auteur(s) :

Aubert-Viard, Francois [Auteur]
Mogrovejo-Valdivia, Alejandra [Auteur]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Maton, Mickael [Auteur]
Chai, Feng [Auteur]
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]

Titre de la revue :

Materials science & engineering. C, Materials for biological applications

Nom court de la revue :

Mater Sci Eng C Mater Biol Appl

Numéro :

100

Pagination :

554-563

Date de publication :

2019-07-01

ISSN :

1873-0191

Mot(s)-clé(s) :

Antibacterial textile
Chitosan
Layer-by-layer
Chlorhexidine
Cyclodextrin
Cytocompatibility
Genipin

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) ...
Lire la suite >The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) (PET) of the dressing was first modified by chitosan (CHT) crosslinked with genipin (Gpn). Parameters such as the concentration of reagents (Gpn and CHT) but also the crosslinking time and the working temperature were optimized to reach the maximal positive charges surface density. This support was then treated by the layer-by-layer (LbL) deposition of a multilayer system composed of methyl-beta-cyclodextrin polymer (PCD) (anionic) and CHT (cationic). After a thermal treatment to stabilize the LbL film, the textiles were loaded with CHX as antiseptic agent. The influence of the thermal treatment i) on the cytocompatibility, ii) on the degradation of the multilayer system, iii) on CHX sorption and release profiles and iv) on the antibacterial activity of the loaded textiles was studied.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
ENSCL
INRA
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité Matériaux et Transformations (UMET) - UMR 8207

Date de dépôt :

2021-01-20T15:59:12Z