Titre :

Controlled release tablets based on hpmc:lactose blends

Auteur(s) :

Moussa, E. [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Leterme-Flament, Marie-Pierre [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Benzine, Youcef [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Penz, Franz Karl [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Karrout, Youness [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]

Titre de la revue :

Journal of Drug Delivery Science and Technology

Nom court de la revue :

J. Drug Deliv. Sci. Technol.

Numéro :

52

Pagination :

607-617

Date de publication :

2019-08-01

ISSN :

1773-2247

Mot(s)-clé(s) :

HPMC
Controlled release
Direct compression
Lactose
Tablet

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to ...
Lire la suite >Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to investigate the importance of the type of preparation technique of propranolol HCl loaded matrix tablets based on such HPMC:lactose blends. The tablets were prepared by: (i) direct compression of physical blends of drug, HPMC and lactose, (ii) direct compression of blends of the drug and co-processed HPMC:lactose (spray agglomerated), and (iii) via wet granulation. Interestingly, the co-processed HPMC:lactose particles provided better flowability and compactability than the physical HPMC:lactose blends, while the resulting water uptake kinetics and drug release rates were similar. Also wet granulation led to similar drug release kinetics. Thus, the use of co-processed HPMC:lactose can offer interesting technical advantages for the manufacturing of controlled release matrix tablets, while system performance remains unaltered.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Date de dépôt :

2021-01-20T15:59:16Z
2024-02-23T13:13:41Z