Title :

Controlled release tablets based on hpmc:lactose blends

Author(s) :

Moussa, E. [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Siepmann, Florence [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Leterme-Flament, Marie-Pierre [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Benzine, Youcef [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Penz, Franz Karl [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Siepmann, Juergen [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Karrout, Youness [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

Journal of Drug Delivery Science and Technology

Abbreviated title :

J. Drug Deliv. Sci. Technol.

Volume number :

52

Pages :

607-617

Publication date :

2019-08-01

ISSN :

1773-2247

Keyword(s) :

HPMC
Controlled release
Direct compression
Lactose
Tablet

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to ...
Show more >Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to investigate the importance of the type of preparation technique of propranolol HCl loaded matrix tablets based on such HPMC:lactose blends. The tablets were prepared by: (i) direct compression of physical blends of drug, HPMC and lactose, (ii) direct compression of blends of the drug and co-processed HPMC:lactose (spray agglomerated), and (iii) via wet granulation. Interestingly, the co-processed HPMC:lactose particles provided better flowability and compactability than the physical HPMC:lactose blends, while the resulting water uptake kinetics and drug release rates were similar. Also wet granulation led to similar drug release kinetics. Thus, the use of co-processed HPMC:lactose can offer interesting technical advantages for the manufacturing of controlled release matrix tablets, while system performance remains unaltered.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Submission date :

2021-01-20T15:59:16Z
2024-02-23T13:13:41Z