Coloring of plga implants to better understand the underlying drug release mechanisms

Bode, C.; Kranz, Heiko; Siepmann, Florence; Siepmann, Juergen

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.ijpharm.2019.118563

PMID :

31351179

Permalink :

http://hdl.handle.net/20.500.12210/37043

Title :

Coloring of plga implants to better understand the underlying drug release mechanisms

Author(s) :

Bode, C. [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Kranz, Heiko [Auteur]
Bayer Pharma AG [Berlin]
Siepmann, Florence [Auteur]

Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]

Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

International Journal of Pharmaceutics

Abbreviated title :

Int J Pharm

Volume number :

569

Pages :

118563

Publication date :

2019-07-24

ISSN :

1873-3476

Keyword(s) :

Implant
PLGA
Drug release mechanism
Swelling
Diffusion

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Different dyes and a colored vitamin (riboflavin) were used to better understand the underlying drug release mechanisms in poly(lactic-co-glycolic acid) (PLGA)-based implants. The latter were prepared by hot melt extrusion ...
Show more >Different dyes and a colored vitamin (riboflavin) were used to better understand the underlying drug release mechanisms in poly(lactic-co-glycolic acid) (PLGA)-based implants. The latter were prepared by hot melt extrusion (HME) or formed in-situ, upon solvent exchange when injecting a PLGA solution in N-methyl-pyrrolidone (NMP) into phosphate buffer pH 7.4. Methylene blue was used as water-soluble dye to stain the release medium, riboflavin as a yellow, water-soluble "model drug", and Sudan-III-red as poorly water-soluble dye, incorporated in the implant. In the case of pre-formed HME implants, the "orchestrating" role of polymer swelling for the control of drug release could be visualized: At early time points, only limited amounts of water penetrate into the system, insufficient for noteworthy drug dissolution and diffusion. However, bulk erosion starts, and once a critical polymer molecular weight threshold value is reached, substantial implant swelling sets on: Large amounts of water come in and allow for significant drug dissolution and diffusion. In the case of in-situ forming implants, the importance of the composition of the liquid formulation for the resulting inner implant structure could be visualized. The latter affects the rate and extent at which water penetrates into the system and, thus, the resulting drug release rate.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

Advanced Drug Delivery Systems (ADDS) - U1008

Submission date :

2021-01-20T15:59:16Z
2024-02-23T11:55:45Z

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Version	Link	Modification date
2	20.500.12210/37043*	2024-02-23T11:53:30Z
1	20.500.12210/37043.1	2021-01-20T15:59:16Z

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Coloring of plga implants to better ...

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