Eudragit rl-based film coatings: how to minimize sticking and adjust drug release using mas

Rongthong, Thitiphorn; Sungthongjeen, Srisagul; Siepmann, Florence; Siepmann, Juergen; Pongjanyakul, Thaned

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.ejpb.2020.01.011

PMID :

31982576

URL permanente :

http://hdl.handle.net/20.500.12210/37055

Titre :

Eudragit rl-based film coatings: how to minimize sticking and adjust drug release using mas

Auteur(s) :

Rongthong, Thitiphorn [Auteur]
Sungthongjeen, Srisagul [Auteur]
Siepmann, Florence [Auteur]

Advanced Drug Delivery Systems (ADDS) - U1008
106179|||Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Siepmann, Juergen [Auteur]

Titre de la revue :

European Journal of Pharmaceutics and Biopharmaceutics

Nom court de la revue :

Eur J Pharm Biopharm

Date de publication :

2020-01-23

ISSN :

1873-3441

Mot(s)-clé(s) :

Quaternary polymethacrylate
Eudragit RL
Drug release
Tablet coating
Magnesium aluminum silicate

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Polymeric film coatings based on quaternary polymethacrylates (QPMs, e.g. Eudragits®) are frequently used for controlled release applications. However, their considerable sticking tendency is a major drawback in practice. ...
Lire la suite >Polymeric film coatings based on quaternary polymethacrylates (QPMs, e.g. Eudragits®) are frequently used for controlled release applications. However, their considerable sticking tendency is a major drawback in practice. In this study, different amounts of magnesium aluminum silicate (MAS) were added to the film coatings in order to overcome this hurdle. MAS is negatively charged and can electrostatically interact with the positively charged QPM. Different types of tablet cores were coated with aqueous Eudragit® RL 30D dispersions, optionally containing varying amounts of MAS. Dynamic changes in the wet mass of the systems as well as drug release upon exposure to 0.1 M HCl and phosphate buffer pH 6.8 were monitored. Propranolol HCl, acetaminophen, and diclofenac sodium were used as cationic, nonionic and anionic model drugs. The tablets were optionally cured for 12 h at 45 or 60 °C. Importantly, the addition of MAS to aqueous Eudragit® RL 30D dispersion substantially reduced the films' stickiness and led to stable inner coating structures, even without curing. Desired drug release rates can be adjusted by varying the QPM:MAS ratio and coating level.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Advanced Drug Delivery Systems (ADDS) - U1008

Date de dépôt :

2021-01-20T15:59:20Z
2024-01-22T12:28:12Z

Numéro de version	Lien	Date de modification
2	20.500.12210/37055*	2024-01-22T12:26:59Z
1	20.500.12210/37055.1	2021-01-20T15:59:20Z

Eudragit rl-based film coatings: how to ...

BibTeX

CSV

Excel

RIS

Historique des modifications

Eudragit rl-based film coatings: how to ... BibTeX CSV Excel RIS

Historique des modifications

Eudragit rl-based film coatings: how to ...

BibTeX

CSV

Excel

RIS