Titre :

Injection molded capsules for colon delivery combining time-controlled and enzyme-triggered approaches

Auteur(s) :

Casati, Federica [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Melocchi, Alice [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Moutaharrik, Saliha [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Uboldi, Marco [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Foppoli, Anastasia [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Maroni, Alessandra [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Zema, Lucia [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Siepmann, Florence [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Gazzaniga, Andrea [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]

Titre de la revue :

International Journal of Molecular Sciences

Nom court de la revue :

Int. J. Mol. Sci.

Numéro :

21

Date de publication :

2020-03-11

Mot(s)-clé(s) :

injection molding
capsules
colon delivery
bacteria-sensitive polymer
soluble hydrophilic polymer
swellable

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

A new type of colon targeting system is presented, combining time-controlled and enzyme-triggered approaches. Empty capsule shells were prepared by injection molding of blends of a high-amylose starch and hydroxypropyl ...
Lire la suite >A new type of colon targeting system is presented, combining time-controlled and enzyme-triggered approaches. Empty capsule shells were prepared by injection molding of blends of a high-amylose starch and hydroxypropyl methylcellulose (HPMC) of different chain lengths. The dissolution/erosion of the HPMC network assures a time-controlled drug release, i.e., drug release starts upon sufficient shell swelling/dissolution/erosion. In addition, the presence of high-amylose starch ensures enzyme-triggered drug release. Once the colon is reached, the local highly concentrated bacterial enzymes effectively degrade this polysaccharide, resulting in accelerated drug release. Importantly, the concentration of bacterial enzymes is much lower in the upper gastrointestinal tract, thus enabling site-specific drug delivery. The proposed capsules were filled with acetaminophen and exposed to several aqueous media, simulating the contents of the gastrointestinal tract using different experimental setups. Importantly, drug release was pulsatile and occurred much faster in the presence of fecal samples from patients. The respective lag times were reduced and the release rates increased once the drug started to be released. It can be expected that variations in the device design (e.g., polymer blend ratio, capsule shell geometry and thickness) allow for a large variety of possible colon targeting release profiles.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-01-20T15:59:23Z
2021-01-25T11:40:13Z