Title :

Designed sponges based on chitosan and cyclodextrin polymer for a local release of ciprofloxacin in diabetic foot infections

Author(s) :

Gauzit Amiel, Alice [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Palomino Durand, Carla [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Lopez, Marco [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Cazaux, Frederic [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Foligne, Benoit [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]

Journal title :

International Journal of Pharmaceutics

Abbreviated title :

Int J Pharm

Volume number :

587

Pages :

119677

Publication date :

2020-07-24

ISSN :

1873-3476

Keyword(s) :

Diabetic foot infection
Chitosan
Polyelectrolyte complex
Cyclodextrin polymer
Ciprofloxacin
Sponge

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Diabetic foot infections are the most common complications requiring hospitalisation of patients with diabetes. They often result in amputation to extremities and are associated with high morbi-mortality rates, especially ...
Show more >Diabetic foot infections are the most common complications requiring hospitalisation of patients with diabetes. They often result in amputation to extremities and are associated with high morbi-mortality rates, especially when bone is infected. Treatment of these complications is based on surgical procedures, nursing care and systemic antibiotic therapy for several weeks, with a significant risk of relapse. Due to low blood flow and damage caused by diabetic foot infection, blood supply is decreased, causing low antibiotic diffusion in the infected site and an increase of possible bacterial resistance, making this type of infection particularly difficult to treat. In this context, the aim of this work was to develop a medical device for local antibiotic release. The device is a lyophilized physical hydrogel, i.e a sponge based on two oppositely charged polyelectrolytes (chitosan and poly(cyclodextrin citrate)). Cyclodextrins, via inclusion complexes, increase drug bioavailability and allow an extended release. Using local release administration increases concentrations in the wound without risk of toxicity to the body and prevents the emergence of resistant bacteria. The hydrogel was characterised by rheology. After freeze-drying, a curing process was implemented. The swelling rate and cell viability were evaluated, and finally, the sponge was impregnated with a ciprofloxacin solution to evaluate its drug release profile and its antibacterial activity.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité Matériaux et Transformations (UMET) - UMR 8207

Submission date :

2021-01-20T15:59:27Z
2024-02-23T09:20:35Z