Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.

Carey, Guillaume; Görmezoğlu, Meltem; de Jong, Joost J A; Hofman, Paul A M; Backes, Walter H; Dujardin, Kathy; Leentjens, Albert F G

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1002/mds.28404

PMID :

33289195

URL permanente :

http://hdl.handle.net/20.500.12210/37569

Titre :

Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.

Auteur(s) :

Carey, Guillaume [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Görmezoğlu, Meltem [Auteur]
Maastricht University [Maastricht]
de Jong, Joost J A [Auteur]
Maastricht University [Maastricht]
Hofman, Paul A M [Auteur]
Maastricht University [Maastricht]
Backes, Walter H [Auteur]
Maastricht University [Maastricht]
Dujardin, Kathy [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172

Leentjens, Albert F G [Auteur]
Maastricht University [Maastricht]

Titre de la revue :

Movement Disorders

Nom court de la revue :

Mov Disord

Numéro :

Pagination :

327-339

Date de publication :

2020-12-02

ISSN :

1531-8257

Mot(s)-clé(s) en anglais :

Parkinson's disease
anxiety
fear circuit
imaging
limbic circuit

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

The aim of this systematic review was (1) to identify the brain regions involved in anxiety in Parkinson's disease (PD) based on neuroimaging studies and (2) to interpret the findings against the background of dysfunction ...
Lire la suite >The aim of this systematic review was (1) to identify the brain regions involved in anxiety in Parkinson's disease (PD) based on neuroimaging studies and (2) to interpret the findings against the background of dysfunction of the fear circuit and limbic cortico-striato-thalamocortical circuit. Studies assessing anxiety symptoms in PD patients and studies using magnetic resonance imaging, positron emission tomography, or single-photon emission computed tomography were included. The severity of anxiety was associated with changes in the fear circuit and the cortico-striato-thalamocortical limbic circuit. In the fear circuit, a reduced gray-matter volume of the amygdala and the anterior cingulate cortex (ACC); an increased functional connectivity (FC) between the amygdala and orbitofrontal cortex (OFC) and hippocampus and between the striatum and the medial prefrontal cortex (PFC), temporal cortex, and insula; and a reduced FC between the lateral PFC and the OFC, hippocampus, and amygdala were reported. In the cortico-striato-thalamocortical limbic circuit, a reduced FC between the striatum and ACC; a reduced dopaminergic and noradrenergic activity in striatum, thalamus, and locus coeruleus; and a reduced serotoninergic activity in the thalamus were reported. To conclude, anxiety is associated with structural and functional changes in both the hypothesized fear and the limbic cortico-striato-thalamocortical circuits. These circuits overlap and may well constitute parts of a more extensive pathway, of which different parts play different roles in anxiety. The neuropathology of PD may affect these circuits in different ways, explaining the high prevalence of anxiety in PD and also the associated cognitive, motor, and psychiatric symptoms. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Lire moins >

Comité de lecture :

Oui

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2021-03-16T09:18:46Z
2021-03-16T09:35:29Z
2021-03-30T14:58:24Z

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Ce document est diffusé sous licence Attribution 3.0 United States

Historique des modifications

Numéro de version	Lien	Date de modification
3	20.500.12210/37569*	2021-03-30T14:55:12Z
2	20.500.12210/37569.2	2021-03-16T09:33:20Z
1	20.500.12210/37569.1	2021-03-16T09:18:46Z

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