Maternal stress programs accelerated aging ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
Maternal stress programs accelerated aging of the basal ganglia motor system in offspring
Auteur(s) :
Marrocco, Jordan [Auteur]
Rockefeller University [New York]
Verhaeghe, Remy [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Bucci, Domenico [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Di Menna, Luisa [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Traficante, Anna [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Bouwalerh, Hammou [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Van Camp, Gilles [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Ghiglieri, Veronica [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Picconi, Barbara [Auteur]
Fondazione Santa Lucia [IRCCS]
Calabresi, Paolo [Auteur]
Fondazione Santa Lucia [IRCCS]
Ravasi, Laura [Auteur]
Pharmacologie de la mort neuronale et de la plasticité cérébrale
Cisani, Francesca [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Bagheri, Farzaneh [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Pittaluga, Anna [Auteur]
Université de Genève = University of Geneva [UNIGE]
Bruno, Valeria [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Battaglia, Giuseppe [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
MORLEY-FLETCHER, Sara [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Rockefeller University [New York]
Verhaeghe, Remy [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Bucci, Domenico [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Di Menna, Luisa [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Traficante, Anna [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Bouwalerh, Hammou [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Van Camp, Gilles [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Ghiglieri, Veronica [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Picconi, Barbara [Auteur]
Fondazione Santa Lucia [IRCCS]
Calabresi, Paolo [Auteur]
Fondazione Santa Lucia [IRCCS]
Ravasi, Laura [Auteur]
Pharmacologie de la mort neuronale et de la plasticité cérébrale
Cisani, Francesca [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Bagheri, Farzaneh [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Pittaluga, Anna [Auteur]
Université de Genève = University of Geneva [UNIGE]
Bruno, Valeria [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Battaglia, Giuseppe [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
MORLEY-FLETCHER, Sara [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Maccari, Stefania [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Titre de la revue :
Neurobiology of Stress
Nom court de la revue :
Neurobiology of Stress
Pagination :
100265
Éditeur :
Elsevier BV
Date de publication :
2020-11
ISSN :
2352-2895
Mot(s)-clé(s) en anglais :
Nigrostriatal development
Motor behavior
Adenosine receptors
Synaptic proteins
Integrated study
Aging
Motor behavior
Adenosine receptors
Synaptic proteins
Integrated study
Aging
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Early-life stress involved in the programming of stress-related illnesses can have a toxic influence on the functioning of the nigrostriatal motor system during aging. We examined the effects of perinatal stress (PRS) on ...
Lire la suite >Early-life stress involved in the programming of stress-related illnesses can have a toxic influence on the functioning of the nigrostriatal motor system during aging. We examined the effects of perinatal stress (PRS) on the neurochemical, electrophysiological, histological, neuroimaging, and behavioral correlates of striatal motor function in adult (4 months of age) and old (21 months of age) male rats. Adult PRS offspring rats showed reduced dopamine (DA) release in the striatum associated with reductions in tyrosine hydroxylase-positive (TH+) cells and DA transporter (DAT) levels, with no loss of striatal dopaminergic terminals as assessed by positron emission tomography analysis with fluorine-18-l-dihydroxyphenylalanine. Striatal levels of DA and its metabolites were increased in PRS rats. In contrast, D2 DA receptor signaling was reduced and A2A adenosine receptor signaling was increased in the striatum of adult PRS rats. This indicated enhanced activity of the indirect pathway of the basal ganglia motor circuit. Adult PRS rats also showed poorer performance in the grip strength test and motor learning tasks. The aged PRS rats also showed a persistent reduction in striatal DA release and defective motor skills in the pasta matrix and ladder rung walking tests. In addition, the old rats showed large increases in the levels of SNAP-25 and synaptophysin, which are synaptic vesicle-related proteins in the striatum, and in the PRS group only, reductions in Syntaxin-1 and Rab3a protein levels were observed. Our findings indicated that the age-dependent threshold for motor dysfunction was lowered in PRS rats. This area of research is underdeveloped, and our study suggests that early-life stress can contribute to an increased understanding of how aging diseases are programmed in early-life.Lire moins >
Lire la suite >Early-life stress involved in the programming of stress-related illnesses can have a toxic influence on the functioning of the nigrostriatal motor system during aging. We examined the effects of perinatal stress (PRS) on the neurochemical, electrophysiological, histological, neuroimaging, and behavioral correlates of striatal motor function in adult (4 months of age) and old (21 months of age) male rats. Adult PRS offspring rats showed reduced dopamine (DA) release in the striatum associated with reductions in tyrosine hydroxylase-positive (TH+) cells and DA transporter (DAT) levels, with no loss of striatal dopaminergic terminals as assessed by positron emission tomography analysis with fluorine-18-l-dihydroxyphenylalanine. Striatal levels of DA and its metabolites were increased in PRS rats. In contrast, D2 DA receptor signaling was reduced and A2A adenosine receptor signaling was increased in the striatum of adult PRS rats. This indicated enhanced activity of the indirect pathway of the basal ganglia motor circuit. Adult PRS rats also showed poorer performance in the grip strength test and motor learning tasks. The aged PRS rats also showed a persistent reduction in striatal DA release and defective motor skills in the pasta matrix and ladder rung walking tests. In addition, the old rats showed large increases in the levels of SNAP-25 and synaptophysin, which are synaptic vesicle-related proteins in the striatum, and in the PRS group only, reductions in Syntaxin-1 and Rab3a protein levels were observed. Our findings indicated that the age-dependent threshold for motor dysfunction was lowered in PRS rats. This area of research is underdeveloped, and our study suggests that early-life stress can contribute to an increased understanding of how aging diseases are programmed in early-life.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Glycostress
Date de dépôt :
2021-03-23T13:07:09Z
2021-03-24T09:59:54Z
2021-03-24T10:02:30Z
2021-03-24T09:59:54Z
2021-03-24T10:02:30Z
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