Long non-coding RNAs: the tentacles of chromatin remodeler complexes

Neve, Bernadette; Jonckheere, Nicolas; Vincent, Audrey; VAN SEUNINGEN, ISABELLE

Document type :

Article dans une revue scientifique

DOI :

10.1007/s00018-020-03646-0

PMID :

33001247

Title :

Long non-coding RNAs: the tentacles of chromatin remodeler complexes

Author(s) :

Neve, Bernadette [Auteur correspondant]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Jonckheere, Nicolas [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Vincent, Audrey [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
VAN SEUNINGEN, ISABELLE [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]

Journal title :

CELLULAR AND MOLECULAR LIFE SCIENCES

Pages :

1139-1161

Publisher :

Springer Verlag

Publication date :

2020-10-01

ISSN :

1420-682X

English keyword(s) :

ATP-dependent helicase
Nucleosome
Histone and epigenetic regulation

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Chromatin remodeler complexes regulate gene transcription, DNA replication and DNA repair by changing both nucleosome position and post-translational modifications. The chromatin remodeler complexes are categorized into ...
Show more >Chromatin remodeler complexes regulate gene transcription, DNA replication and DNA repair by changing both nucleosome position and post-translational modifications. The chromatin remodeler complexes are categorized into four families: the SWI/SNF, INO80/SWR1, ISWI and CHD family. In this review, we describe the subunits of these chromatin remodeler complexes, in particular, the recently identified members of the ISWI family and novelties of the CHD family. Long non-coding (lnc) RNAs regulate gene expression through different epigenetic mechanisms, including interaction with chromatin remodelers. For example, interaction of lncBRM with BRM inhibits the SWI/SNF complex associated with a differentiated phenotype and favors assembly of a stem cell-related SWI/SNF complex. Today, over 50 lncRNAs have been shown to affect chromatin remodeler complexes and we here discuss the mechanisms involved.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL

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