Title :

Asymptomatic optic nerve lesions an underestimated cause of silent retinal atrophy in ms

Author(s) :

Davion, Jean-Baptiste [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Lopes, Renaud [Auteur]
Lille in vivo imaging and Functional Exploration - PLBS [LiiFE]
Drumez, Elodie [Auteur]
221576|||Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] (VALID)
Labreuche, Julien [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Hadhoum, Nawal [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Lannoy, Julien [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Vermersch, Patrick [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Pruvo, Jean-Pierre [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Leclerc, Xavier [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Zephir, Helene [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Outteryck, Olivier [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

94

Pages :

e2468-e2478

Publisher :

American Academy of Neurology

Publication date :

2020-06-09

ISSN :

0028-3878

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective To evaluate the frequency of asymptomatic optic nerve lesions and their role in the asymptomatic retinal neuroaxonal loss observed in multiple sclerosis (MS). Methods We included patients with remitting-relapsing ...
Show more >Objective To evaluate the frequency of asymptomatic optic nerve lesions and their role in the asymptomatic retinal neuroaxonal loss observed in multiple sclerosis (MS). Methods We included patients with remitting-relapsing MS in the VWIMS study (Analysis of Neurodegenerative Process Within Visual Ways In Multiple Sclerosis) (ClinicalTrials.gov Identifier: 03656055). Included patients underwent optical coherence tomography (OCT), optic nerve and brain MRI, and low-contrast visual acuity measurement. In eyes of patients with MS without optic neuritis (MS-NON), an optic nerve lesion on MRI (3D double inversion recovery [DIR] sequence) was considered as an asymptomatic lesion. We considered the following OCT/MRI measures: peripapillary retinal nerve fiber layer thickness, macular ganglion cell + inner plexiform layer (mGCIPL) volumes, optic nerve lesion length, T2 lesion burden, and fractional anisotropy within optic radiations. Results An optic nerve lesion was detected in half of MS-NON eyes. Compared to optic nerves without any lesion and independently of the optic radiation lesions, the asymptomatic lesions were associated with thinner inner retinal layers (p < 0.0001) and a lower contrast visual acuity (p ≤ 0.003). Within eyes with asymptomatic optic nerve lesions, optic nerve lesion length was the only MRI measure significantly associated with retinal neuroaxonal loss (p < 0.03). Intereye mGCIPL thickness difference (IETD) was lower in patients with bilateral optic nerve DIR hypersignal compared to patients with unilateral hypersignal (p = 0.0317). For the diagnosis of history of optic neuritis, sensitivity of 3D DIR and of mGCIPL IETD were 84.9% and 63.5%, respectively. Conclusions Asymptomatic optic nerve lesions are an underestimated and preponderant cause of retinal neuroaxonal loss in MS. 3D DIR sequence may be more sensitive than IETD measured by OCT for the detection of optic nerve lesions.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires
Neuroinflammation & Multiple Sclerosis (NEMESIS)

Submission date :

2021-06-01T08:08:34Z
2024-03-20T10:32:19Z