Titre :

mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

Auteur(s) :

Ramirez-Moral, I. [Auteur correspondant]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Yu, X. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Butler, J. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
van Weeghel, M. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Otto, N. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Ferreira, B. Lima [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Maele, L. Van [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Sirard, Jean-Claude [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
de Vos, A. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
de Jong, M. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Houtkooper, R. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
van Der Poll, T. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]

Titre de la revue :

Mucosal Immunology

Pagination :

594-604

Éditeur :

Nature Pub. Group

Date de publication :

2021-02-04

ISSN :

1933-0219

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective immune responses. We here sought to determine which metabolic ...
Lire la suite >Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective immune responses. We here sought to determine which metabolic pathways are utilized by HBE cells to mount innate immune responses upon exposure to a relevant bacterial agonist. Stimulation of HBE cells by the bacterial component flagellin triggered activation of the mTOR pathway resulting in an increased glycolytic flux that sustained the secretory activity of immune mediators by HBE cells. The mTOR inhibitor rapamycin impeded glycolysis and limited flagellin-induced secretion of immune mediators. The role of the mTOR pathway was recapitulated in vivo in a mouse model of flagellin-triggered lung innate immune responses. These data demonstrate that metabolic reprogramming via the mTOR pathway modulates activation of the respiratory epithelium, identifying mTOR as a potential therapeutic target to modulate mucosal immunity in the context of bacterial infections.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

Repurposing disused antibiotics with immune modulators as antimicrobial strategy for respiratory tract infections

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL