Title :

mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

Author(s) :

Ramirez-Moral, I. [Auteur correspondant]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Yu, X. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Butler, J. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
van Weeghel, M. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Otto, N. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Ferreira, B. Lima [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Maele, L. Van [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Sirard, Jean-Claude [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
de Vos, A. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
de Jong, M. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Houtkooper, R. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
van Der Poll, T. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]

Journal title :

Mucosal Immunology

Pages :

594-604

Publisher :

Nature Pub. Group

Publication date :

2021-02-04

ISSN :

1933-0219

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective immune responses. We here sought to determine which metabolic ...
Show more >Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective immune responses. We here sought to determine which metabolic pathways are utilized by HBE cells to mount innate immune responses upon exposure to a relevant bacterial agonist. Stimulation of HBE cells by the bacterial component flagellin triggered activation of the mTOR pathway resulting in an increased glycolytic flux that sustained the secretory activity of immune mediators by HBE cells. The mTOR inhibitor rapamycin impeded glycolysis and limited flagellin-induced secretion of immune mediators. The role of the mTOR pathway was recapitulated in vivo in a mouse model of flagellin-triggered lung innate immune responses. These data demonstrate that metabolic reprogramming via the mTOR pathway modulates activation of the respiratory epithelium, identifying mTOR as a potential therapeutic target to modulate mucosal immunity in the context of bacterial infections.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Repurposing disused antibiotics with immune modulators as antimicrobial strategy for respiratory tract infections

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL