Title :

Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population

Author(s) :

Takou, Margarita [Auteur]
Universität zu Köln = University of Cologne
Hämälä, Tuomas [Auteur]
Koch, Evan [Auteur]
Department of Biomedical Informatics [Harvard] [DBMI]
Steige, Kim [Auteur]
Universität zu Köln = University of Cologne
Dittberner, Hannes [Auteur]
Universität zu Köln = University of Cologne
Yant, Levi [Auteur]
Genete, Mathieu [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Sunyaev, Shamil [Auteur]
University of Nottingham, UK [UON]
Castric, Vincent [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Vekemans, Xavier [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Savolainen, Outi [Auteur]
Meaux, Juliette [Auteur]
Universität zu Köln = University of Cologne

Journal title :

Molecular Biology and Evolution

Pages :

1820 - 1836

Publisher :

Oxford University Press (OUP)

Publication date :

2021-01-22

ISSN :

0737-4038

English keyword(s) :

range expansion
adaptation
deleterious mutations
self-incompatibility locus
negative frequencydependent selection
selective sweeps

HAL domain(s) :

Sciences du Vivant [q-bio]/Génétique/Génétique des populations [q-bio.PE]

English abstract : [en]

During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive dynamics, preventing the removal of deleterious mutations and slowing down ...
Show more >During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive dynamics, preventing the removal of deleterious mutations and slowing down adaptation. Here, we contrast populations of the European subspecies Arabidopsis lyrata ssp. petraea, which expanded its Northern range after the last glaciation. We document a sharp decline in effective population size in the range-edge population and observe that nonsynonymous variants segregate at higher frequencies. We detect a 4.9% excess of derived nonsynonymous variants per individual in the range-edge population, suggesting an increase of the genomic burden of deleterious mutations. Inference of the fitness effects of mutations and modeling of allele frequencies under the explicit demographic history of each population predicts a depletion of rare deleterious variants in the range-edge population, but an enrichment for fixed ones, consistent with the bottleneck effect. However, the demographic history of the rangeedge population predicts a small net decrease in per-individual fitness. Consistent with this prediction, the range-edge population is not impaired in its growth and survival measured in a common garden experiment. We further observe that the allelic diversity at the self-incompatibility locus, which ensures strict outcrossing and evolves under negative frequency-dependent selection, has remained unchanged. Genomic footprints indicative of selective sweeps are broader in the Northern population but not less frequent. We conclude that the outcrossing species A. lyrata ssp. petraea shows a strong resilience to the effect of range expansion.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198

Source :

Harvested from HAL