Hyposialylation Must Be Considered to ...
Document type :
Article dans une revue scientifique
DOI :
Permalink :
Title :
Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases
Author(s) :
Bordron, Anne [Auteur]
Morel, Marie [Auteur]
Bagacean, Cristina [Auteur]
Dueymes, Maryvonne [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Lymphocytes B, Autoimmunité et Immunothérapies [LBAI]
Pochard, Pierre [Auteur]
Harduin Lepers, Anne [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Jamin, Christophe [Auteur]
Pers, Jacques-Olivier [Auteur]
Morel, Marie [Auteur]
Bagacean, Cristina [Auteur]
Dueymes, Maryvonne [Auteur]

Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Lymphocytes B, Autoimmunité et Immunothérapies [LBAI]
Pochard, Pierre [Auteur]
Harduin Lepers, Anne [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Jamin, Christophe [Auteur]
Pers, Jacques-Olivier [Auteur]
Journal title :
International Journal of Molecular Sciences
Abbreviated title :
IJMS
Volume number :
22
Pages :
3402
Publisher :
MDPI AG
Publication date :
2021-03-26
ISSN :
1422-0067
English keyword(s) :
sialic acid
sialyltransferase
autoimmune diseases
immunoglobulin
CD22
therapies
sialyltransferase
autoimmune diseases
immunoglobulin
CD22
therapies
HAL domain(s) :
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Immunologie
Chimie/Chimie théorique et/ou physique
Sciences du Vivant [q-bio]/Immunologie
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the ...
Show more >Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the terminal end of glycoproteins and glycolipids is essential for distinguishing between self and non-self-antigens and the control of pro- or anti-inflammatory immune reactions. In autoimmunity, hyposialylation is responsible for chronic inflammation, the anarchic activation of the immune system and organ lesions. A detailed characterization of this mechanism is a key element for improving the understanding of these diseases and the development of innovative therapies. This review focuses on the impact of sialylation in autoimmunity in order to determine future treatments based on the regulation of hyposialylation.Show less >
Show more >Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the terminal end of glycoproteins and glycolipids is essential for distinguishing between self and non-self-antigens and the control of pro- or anti-inflammatory immune reactions. In autoimmunity, hyposialylation is responsible for chronic inflammation, the anarchic activation of the immune system and organ lesions. A detailed characterization of this mechanism is a key element for improving the understanding of these diseases and the development of innovative therapies. This review focuses on the impact of sialylation in autoimmunity in order to determine future treatments based on the regulation of hyposialylation.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Régulation de la glycosylation terminale
Submission date :
2021-06-21T10:08:58Z
2021-06-23T14:05:19Z
2021-06-23T14:05:19Z
Files
- P21.01 Bordron et al ijms 2021 review sialyltion auto immune diseases.pdf
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