MDPV and α-PVP use in humans: The twisted sisters

Karila, Laurent; Lafaye, Geneviève; Scocard, Amandine; Cottencin, Olivier; Benyamina, Amine

Type de document :

Article dans une revue scientifique

DOI :

10.1016/j.neuropharm.2017.10.007

PMID :

29030166

URL permanente :

http://hdl.handle.net/20.500.12210/3971

Titre :

MDPV and α-PVP use in humans: The twisted sisters

Auteur(s) :

Karila, Laurent [Auteur]
Neuroimagerie en psychiatrie [U1000]
Lafaye, Geneviève [Auteur]
Scocard, Amandine [Auteur]
Université de Bordeaux [UB]
Cottencin, Olivier [Auteur]

Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Benyamina, Amine [Auteur]
Hôpital Paul Brousse

Titre de la revue :

Neuropharmacology

Nom court de la revue :

Neuropharmacology

Numéro :

134

Pagination :

65-72

Date de publication :

2017-10-10

ISSN :

1873-7064

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

The new psychoactive substances phenomenon continues to represent a considerable public health challenge. Synthetic cathinones are β-keto amphetamine analogues, also known as legal highs, research chemicals, bath salts. ...
Lire la suite >The new psychoactive substances phenomenon continues to represent a considerable public health challenge. Synthetic cathinones are β-keto amphetamine analogues, also known as legal highs, research chemicals, bath salts. These drugs have surfaced as a popular alternative to other illicit drugs of abuse, such as cocaine, MDMA, and methamphetamine, due to their potent psychostimulant and empathogenic effects. Pyrovalerone cathinones (a-pyrrolidinophenones) form a distinct group of designer cathinones, such as MDPV. After being listed as an illegal product, "second generation" compounds such as α-PVP, sharing a very similar chemical structure with MDPV, were developed. Clinical effects of these compounds are individual, dose- and route of administration-dependent. Both of them have been involved in an increased number of, not only acute intoxications but also fatalities over the past few years, raising concerns in the medical field. In this paper, we will review the available data regarding the use and effects of MDPV and α-PVP in humans in order to highlight their impact on public health. Health actors and general population need to be clearly informed of potential risks and consequences of these 2 novel psychoactive substances spread and use. The literature search conducted led to the identification of potentially 83 relevant articles. All articles were screened from their abstracts to determine their relevance in the framework of the current review.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
CNRS
CHU Lille

Collections :

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Équipe(s) de recherche :

Équipe Psychiatrie & Croyance (PsyCHIC)

Date de dépôt :

2019-02-13T14:17:48Z
2020-04-03T08:25:16Z

Numéro de version	Lien	Date de modification
2	20.500.12210/3971*	2020-04-03T08:19:32Z
1	20.500.12210/3971.1	2019-02-13T14:17:48Z

MDPV and α-PVP use in humans: The twisted sisters

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MDPV and α-PVP use in humans: The twisted sisters

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