Clinical spectrum and prognostic value of ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Clinical spectrum and prognostic value of cns mog autoimmunity in adults: the mogador study
Author(s) :
Cobo-Calvo, Alvaro [Auteur]
Ruiz, Anne [Auteur]
Maillart, Elisabeth [Auteur]
Audoin, Bertrand [Auteur]
ZEPHIR, Helene [Auteur]
Bourre, Bertrand [Auteur]
Ciron, Jonathan [Auteur]
Collongues, Nicolas [Auteur]
Brassat, David [Auteur]
Cotton, Francois [Auteur]
Papeix, Caroline [Auteur]
Durand-Dubief, Francoise [Auteur]
Laplaud, David [Auteur]
Deschamps, Romain [Auteur]
Cohen, Mikael [Auteur]
Biotti, Damien [Auteur]
Ayrignac, Xavier [Auteur]
Tilikete, Caroline [Auteur]
Thouvenot, Eric [Auteur]
Brochet, Bruno [Auteur]
Dulau, Cecile [Auteur]
Moreau, Thibault [Auteur]
Tourbah, Ayman [Auteur]
Lebranchu, Pierre [Auteur]
Michel, Laure [Auteur]
Lebrun-Frenay, Christine [Auteur]
Montcuquet, Alexis [Auteur]
Mathey, Guillaume [Auteur]
Debouverie, Marc [Auteur]
Pelletier, Jean [Auteur]
Labauge, Pierre [Auteur]
Derache, Nathalie [Auteur]
Coustans, Marc [Auteur]
Rollot, Fabien [Auteur]
De Seze, Jerome [Auteur]
Vukusic, Sandra [Auteur]
Marignier, Romain [Auteur]
Ruiz, Anne [Auteur]
Maillart, Elisabeth [Auteur]
Audoin, Bertrand [Auteur]
ZEPHIR, Helene [Auteur]
Bourre, Bertrand [Auteur]
Ciron, Jonathan [Auteur]
Collongues, Nicolas [Auteur]
Brassat, David [Auteur]
Cotton, Francois [Auteur]
Papeix, Caroline [Auteur]
Durand-Dubief, Francoise [Auteur]
Laplaud, David [Auteur]
Deschamps, Romain [Auteur]
Cohen, Mikael [Auteur]
Biotti, Damien [Auteur]
Ayrignac, Xavier [Auteur]
Tilikete, Caroline [Auteur]
Thouvenot, Eric [Auteur]
Brochet, Bruno [Auteur]
Dulau, Cecile [Auteur]
Moreau, Thibault [Auteur]
Tourbah, Ayman [Auteur]
Lebranchu, Pierre [Auteur]
Michel, Laure [Auteur]
Lebrun-Frenay, Christine [Auteur]
Montcuquet, Alexis [Auteur]
Mathey, Guillaume [Auteur]
Debouverie, Marc [Auteur]
Pelletier, Jean [Auteur]
Labauge, Pierre [Auteur]
Derache, Nathalie [Auteur]
Coustans, Marc [Auteur]
Rollot, Fabien [Auteur]
De Seze, Jerome [Auteur]
Vukusic, Sandra [Auteur]
Marignier, Romain [Auteur]
Journal title :
Neurology
Abbreviated title :
Neurology
Publication date :
2018-04-25
ISSN :
1526-632X
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
To describe clinical and radiologic features associated with myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) in a large French nationwide adult cohort, to assess baseline prognostic features of MOG-Ab-associated ...
Show more >To describe clinical and radiologic features associated with myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) in a large French nationwide adult cohort, to assess baseline prognostic features of MOG-Ab-associated diseases after a first acute demyelinating syndrome, and to evaluate the clinical value of MOG-Ab longitudinal analysis. Clinical data were obtained from 197 MOG-Ab-positive patients ≥18 years of age. Complete imaging data were available in 108, and 54 serum samples were eligible for longitudinal evaluation. For survival analysis comparison, 169 aquaporin-4 antibody (AQP4-Ab)-positive patients from the NOMADMUS database were included. Median age at onset was 36.46 (range 18.0-76.8) years, and patients were predominantly white (92.9%) with male:female ratio, 1.1. Clinical phenotype at onset included optic neuritis or myelitis in 90.86%, isolated brainstem or encephalopathy syndromes in 6.6%, and a combination of syndromes in 2.5%. Distinctive brain MRI findings in MOG-Ab-positive patients were thalamic and pontine lesions. Cortical and leptomeningeal lesions were found in 16.3% and 6.1%, respectively. The probability of reaching a first relapse after 2 and 5 years was 44.8% and 61.8%, respectively. MOG-Ab-positive patients were at lower risk at presentation of further clinical relapse (hazard ratio [HR] 0.45, 95% confidence interval [CI] 0.26-0.79) compared to AQP4-Ab-positive individuals. MOG-Ab-positive individuals had a lower risk of reaching Disability Status Scale score of 3.0 (HR 0.46, 95% CI 0.22-0.94) and visual acuity of 20/100 (HR 0.23, 95% CI 0.07-0.72). Finally, MOG-Ab titers were higher at relapse than in remission (p In adults, MOG-Ab-associated disease extends beyond clinical and radiologic abnormalities in the optic nerve and spinal cord. Despite the relapsing course, the overall visual and motor outcome is better compared with AQP4-Ab-positive patients.Show less >
Show more >To describe clinical and radiologic features associated with myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) in a large French nationwide adult cohort, to assess baseline prognostic features of MOG-Ab-associated diseases after a first acute demyelinating syndrome, and to evaluate the clinical value of MOG-Ab longitudinal analysis. Clinical data were obtained from 197 MOG-Ab-positive patients ≥18 years of age. Complete imaging data were available in 108, and 54 serum samples were eligible for longitudinal evaluation. For survival analysis comparison, 169 aquaporin-4 antibody (AQP4-Ab)-positive patients from the NOMADMUS database were included. Median age at onset was 36.46 (range 18.0-76.8) years, and patients were predominantly white (92.9%) with male:female ratio, 1.1. Clinical phenotype at onset included optic neuritis or myelitis in 90.86%, isolated brainstem or encephalopathy syndromes in 6.6%, and a combination of syndromes in 2.5%. Distinctive brain MRI findings in MOG-Ab-positive patients were thalamic and pontine lesions. Cortical and leptomeningeal lesions were found in 16.3% and 6.1%, respectively. The probability of reaching a first relapse after 2 and 5 years was 44.8% and 61.8%, respectively. MOG-Ab-positive patients were at lower risk at presentation of further clinical relapse (hazard ratio [HR] 0.45, 95% confidence interval [CI] 0.26-0.79) compared to AQP4-Ab-positive individuals. MOG-Ab-positive individuals had a lower risk of reaching Disability Status Scale score of 3.0 (HR 0.46, 95% CI 0.22-0.94) and visual acuity of 20/100 (HR 0.23, 95% CI 0.07-0.72). Finally, MOG-Ab titers were higher at relapse than in remission (p In adults, MOG-Ab-associated disease extends beyond clinical and radiologic abnormalities in the optic nerve and spinal cord. Despite the relapsing course, the overall visual and motor outcome is better compared with AQP4-Ab-positive patients.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Neuroinflammation & Multiple Sclerosis (NEMESIS)
Submission date :
2021-06-23T11:42:33Z